Tratamiento radioterápico en la oftalmopatía de Graves

Article information

Antecedentes

Hemos analizado de forma retrospectiva 36 pacientes diagnosticados de oftalmopatía de Graves tratados con radioterapia.

Métodos

Hemos tratado 36 pacientes, 30 habían sido tratados previamente con glucocorticoides.

El tratamiento se ha realizado en un acelerador lineal de electrones de 8 Mv con dos campos bilaterales y una dosis total de 20 Gy, fraccionada en 10 sesiones de 2 Gy. Los parámetros medidos han sido la proptosis, la afección de partes blandas, la diplopía y la agudeza visual.

Resultados

La afección de partes blandas mejoró en un 66%, la proptosis en un 55%, la diplopía en un 35% y la agudeza visual en un 20% (p = 0,06).

Conclusiones

La radioterapia orbitaria puede mejorar la mayoría de los signos y síntomas de la oftalmopatía de Graves.

Palabras clave:

Oftalmopatía tiroidea

de Graves

Radioterapia

History

A retrospective analysis of 36 patients with Graves’ ophthalmopathy and treated with radiotherapy.

Methods

We have treated 36 patients, 30 had been previously treated with corticosteroids. All 36 patients were treated with an 18 Mv linear accelerator, by which 20 Gy was delivered to the midplane of both orbits in ten fractions. The studied parameters were: soft tissue impairment, proptosis, diplopia and visual acuity.

Results

Soft tissue signs improved with a response rate of 66%, proptosis 55%, diplopia 30% and visual acuity 15% (p = 0,06).

Conclusions

Orbital radiotherapy can result in improvement in signs and symptoms of Graves’ ophthalmopathy in the majority of patients.

Key words:

Graves’ ophthalmopathy

Radiotherapy

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