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Vol. 33. Issue 6.
Pages 289-295 (November - December 2021)
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Vol. 33. Issue 6.
Pages 289-295 (November - December 2021)
Original article
Relationship of serum vitamin D deficiency with coronary artery disease severity using multislice CT coronary angiography
Relación entre el déficit de vitamina D sérico y la gravedad de la arteriopatía coronaria evaluada mediante angio-TAC multicortes
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Mostafa El Mokadema,
Corresponding author
mostafa.elmokadem9@gmail.com

Corresponding author.
, Hesham Boshraa, Yasser Abd el Hadya, Alshimaa Saber Abd el Hameedb
a Cardiology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
b Cardiology Department, Police Hospital Nasr City, Cairo, Egypt
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Tables (5)
Table 1. Baseline characteristics of all patients under study (n=100).
Table 2. CT angiographic results.
Table 3. Comparison between patients with vitamin D deficiency and those with normal vitamin D level regarding CT angiographic results.
Table 4. Correlation between vitamin D (ng/ml) level and severity of coronary lesions.
Table 5. Multivariate linear regression analysis for independent predictors of percent severity of coronary stenosis and number of diseased coronary vessels.
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Abstract
Aim

To assess the relationship between vitamin D deficiency and severity of coronary artery disease using multislice CT coronary angiography.

Methods

100 patients diagnosed with coronary artery disease during multislice CT coronary angiography were subjected to full evaluation of coronary artery disease severity followed by measurement of serum vitamin D level.

Results

The mean value of serum vitamin D level was 13.35±7.49ng/ml. 76% of the patients had vitamin D deficiency (<20ng/ml). 41% of the patients had single vessel disease, 28% had two vessel diseases, and 31% had multi-vessel disease. Patients with vitamin D deficiency had higher degree of coronary stenosis, higher coronary Ca score (p<0.001) and higher number of affected vessels compared with normal vitamin D level subgroup (p<0.001). Vitamin D level showed a significant negative correlations with age (r=−0.290, p=0.003), coronary Ca score (r=−0.630, p<0.001) and severity of coronary lesions. Multivariate linear regression analysis showed that dyslipidemia and vitamin D level were independent predictors of percent severity of coronary stenosis.

Conclusion

In addition to traditional cardiovascular risk factors, vitamin D deficiency looks to be independent predictor of coronary artery disease severity including percent stenosis, number of the affected vessels as well as degree of coronary calcification.

Keywords:
Vitamin D
Coronary artery disease
Coronary stenosis
Ca score
Abbreviations:
CAD
CTA
DM
CAC
25(OH)D3
HTN
VDR
Resumen
Objetivo

Evaluar la relación entre el déficit de vitamina D y la gravedad de la arteriopatía coronaria mediante angio-TAC coronaria multicortes.

Métodos

Cien pacientes con diagnóstico de arteriopatía coronaria durante la realización de angio-TAC multicortes fueron sometidos a evaluación completa de la gravedad de la enfermedad tras la medición del nivel de vitamina D sérico.

Resultados

El valor medio del nivel de vitamina D sérico fue de 13,35 ± 7,49 ng/ml. El 76% de los pacientes tenían déficit de vitamina D (<20 ng/ml). El 41% de los pacientes tenía afectado un único vaso, y el 28% tenía afectados dos vasos, y el 31% tenía afectados múltiples vasos. Los pacientes con déficit de vitamina D tenían un mayor grado de estenosis coronaria, mayor puntuación de Ca coronario (p < 0,001) y un mayor número de vasos afectados en comparación con el subgrupo con un nivel normal de vitamina D (p < 0,001). El nivel de vitamina D reflejó correlaciones negativas significativas con la edad (r = −0,290, p = 0,003), puntuación de Ca coronario (r = −0,630, p < 0,001) y gravedad de las lesiones coronarias. El análisis de regresión lineal multivariante reflejó que la dislipidemia y el nivel de vitamina D eran factores predictivos independientes del porcentaje de gravedad de la estenosis coronaria.

Conclusión

Además de los factores tradicionales de riesgo cardiovascular, el déficit de vitamina D parece ser un factor predictivo independiente de la gravedad de la arteriopatía coronaria incluyendo el porcentaje de estenosis, el número de vasos afectados y el grado de calcificación coronaria.

Palabras clave:
Vitamina D
Arteriopatía coronaria
Estenosis coronaria
Puntuación de Ca coronario.

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