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Vol. 33. Issue 5.
Pages 217-223 (September - October 2021)
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Vol. 33. Issue 5.
Pages 217-223 (September - October 2021)
Original article
Prevalence of severe hypercholesterolemia observed in different hospitals in Andalusia and Ceuta
Prevalencia de hipercolesterolemias severas observadas en los distintos hospitales de Andalucía y Ceuta
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Teresa Arrobas Velillaa,
Corresponding author
, Gema Varo Sánchezb, Irene Romero Garcíac, Enrique Melguizo Madridd, Firma Isabel Rodríguez Sáncheze, Antonio León Justela, in collaboration with the vascular risk workgroup of Andalusia
a Laboratorio Bioquímica Clínica, Hospital Universitario Virgen Macarena, Sevilla, Spain
b Laboratorio Hospital de Río Tinto, Huelva, Spain
c Laboratorio Hospital Universitario de Jaén, Jaén, Spain
d Laboratorio de Bioquímica Clínica, Hospital Universitario Virgen del Rocío, Sevilla, Spain
e Laboratorio Hospital Universitario de Torrecárdenas, Málaga, Spain
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Table 1. Number de patients ≥18 years and cholesterol attached to low density lipoproteins >250 mg/dl and number of patients <18 years and cholesterol attached to low density lipoproteins >135 mg/dl classified by hospital centres, number of analyses with cholesterol attached to low density lipoproteins in 2018 and reference population.
Table 2. Number of patients ≥18 years and cholesterol attached to low density lipoproteins >250 mg/dl and number of patients <18 years and cholesterol attached to low density lipoproteins >135 mg/dl classified by provinces, total number of analyses which contain lipid profile and prevalence.
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Abstract

Severe hypercholesterolaemia is a major cardiovascular risk factor. Early detection and treatment can reduce the incidence of cardiovascular disease. Given the high prevalence of hypercholesterolaemia in Andalusia, the development of a screening strategy for its detection in Primary Care may be an efficient measure.

Objective

To identify patients in Primary Care with severe hypercholesterolaemia that may increase their cardiovascular risk by reviewing LDL-cholesterol results in computerised laboratory systems.

Material and methods

Observational, retrospective, multi-centre study in 16 hospitals in Andalusia and Ceuta. Anonymous analytical data were acquired from the different laboratory computer systems for the year 2018, and exclusively from Macarena Hospital for the year 2019.

Results

From a total of 1,969,035 determinations on ≥18 years old, 2791 patients (0.14%) were detected with LDL-cholesterol >250 mg/dl and from a total of 2.327.211 determinations studied in children under 18 years old, 3804 patients (0.16%) were detected with LDL-cholesterol >135 mg/dl. The highest incidence of possible genetic hypercholesterolaemia in adults corresponded to the province of Seville with 23.6 cases/1000 determinations, while in minors, the highest incidence corresponded to the province of Cadiz with 75 possible cases/1000 determinations. A geographical triangle of greater prevalence is observed between the provinces of Seville, Huelva and Cadiz.

Conclusions

The development of a screening strategy using a computerised review of LDL-cholesterol in Primary Care detects a large number of subjects with severe hypercholesterolaemia that could benefit from an early intervention.

Keywords:
Dyslipidaemia
Prevalence
Cardiovascular risk factors
Andalusia
Laboratory
Resumen

La hipercolesterolemia severa es un importante factor de riesgo cardiovascular. Su detección precoz y tratamiento puede reducir la incidencia de las enfermedades cardiovasculares. Dada la alta prevalencia de hipercolesterolemia en Andalucía, el desarrollo de una estrategia oportunista para su detección en atención primaria puede ser una medida eficiente.

Objetivo

Identificar pacientes en atención primaria con hipercolesterolemias severas que puedan incrementar su riesgo cardiovascular mediante una consulta del colesterol- LDL al sistema informático de laboratorio.

Material y métodos

Estudio observacional, retrospectivo, multicéntrico, en 16 hospitales de Andalucía y Ceuta. Se adquirieron datos analíticos anonimizados de los diferentes sistemas informáticos de laboratorio del año 2018 y exclusivamente del Hospital Virgen Macarena para el año 2019.

Resultados

De un total de 1.969.035 determinaciones ≥ 18 años se detectaron 2.791 pacientes (0,14%) con colesterol-LDL > 250 mg/dl, y en menores de 18 años, sobre un total de 2.327.211 determinaciones estudiadas, se detectaron 3.804 pacientes (0,16%) con colesterol-LDL > 135 mg/dl. La mayor incidencia de posibles hipercolesterolemias genéticas en adultos correspondió a la provincia Sevilla con 23,6 casos/1.000 determinaciones, mientras que en menores la mayor incidencia correspondió a la provincia de Cádiz, con 75 posibles casos/1.000 determinaciones. Se observa un triángulo geográfico de mayor prevalencia entre las provincias de Sevilla, Huelva y Cádiz.

Conclusiones

El desarrollo de una estrategia oportunista mediante consulta informática del colesterol-LDL en atención primaria detecta un gran número de sujetos con hipercolesterolemias severas que se podrían beneficiar de una intervención precoz.

Palabras clave:
Dislipemia
Prevalencia
Factores de riesgo cardiovascular
Andalucía
Laboratorio

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