Buscar en
Clínica e Investigación en Arteriosclerosis (English Edition)
Toda la web
Inicio Clínica e Investigación en Arteriosclerosis (English Edition) Familial hypercholesterolemia: Experience in the Lipid Clinic of Alava
Journal Information
Vol. 30. Issue 5.
Pages 224-229 (September - October 2018)
Share
Share
Download PDF
More article options
ePub
Visits
0
Vol. 30. Issue 5.
Pages 224-229 (September - October 2018)
Brief report
DOI: 10.1016/j.artere.2018.04.003
Familial hypercholesterolemia: Experience in the Lipid Clinic of Alava
Hipercolesterolemia familiar: experiencia en la Unidad de Lípidos de Álava
Visits
...
Leire Pérez García
Unidad de Lípidos, Hospital Universitario Araba, Vitoria, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Tables (2)
Table 1. Sociodemographic and clinical characteristics and baseline lipid values.
Table 2. Lipid-lowering treatment.
Show moreShow less
Abstract
Introduction

Familial hypercholesterolaemia (FH) is the autosomal dominant genetic disorder most frequently associated with premature cardiovascular disease (CVD).

Materials and methods

A retrospective, observational study was conducted to determine the clinical characteristics, analytical parameters and cardiovascular risk factors of 133 patients with a genetically confirmed diagnosis of FH on follow-up in the Lipid Clinic of Alava.

Results

CVD was observed in 8.30% of the patients (ischaemic heart disease in 100% of the cases). The LDL concentration goal was achieved in 40.6% (45.50% in primary prevention and 27.30% in secondary prevention). The large majority (81.80%) of patients with coronary heart disease (CHD) were male. The odds ratio (OR) of males having CHD compared to females is 4.97 (1.03–23.93, p=0.03). The OR of developing CHD in patients with a family history of premature CVD is 6.86 (1.32–35.67, p=p.02). A statistically significant association was found between smoking and the risk of CVD (p=0.005), and also between having diabetes and the risk of CVD (p=0.0001). If the treatment with statins begins at older than 40 years, the OR of suffering CHD is 6.40 (1.53–26.5) (p=0.009). The mean time from diagnosis to the cardiovascular event in the group of ex-smokers is 10.80±5.80 years, and in the non-smoking group it is 17.50±2.50 years (p=0.011).

Conclusions

In our reference population with FH, it was found that there was an increased risk of suffering a cardiovascular event in male patients, with a family history of premature CVD, diabetics, and in those in whom lipid lowering treatment was started after 40 years of age.

Keywords:
Familial hypercholesterolaemia
Cardiovascular risk factors
Cardiovascular disease
Resumen
Introducción

La hipercolesterolemia familiar (HF) es el trastorno genético autosómico dominante más frecuentemente asociado a enfermedad cardiovascular (ECV) prematura.

Material y métodos

Estudio observacional, retrospectivo, para determinar las características clínicas, los parámetros analíticos y los factores de riesgo cardiovascular de 133 pacientes con diagnóstico genético confirmado de HF en seguimiento en la Unidad de Lípidos de Álava.

Resultados

El 8,30% de los pacientes ha presentado ECV (en el 100% de los casos cardiopatía isquémica [CI]). El 40,60% alcanza el objetivo de cLDL: el 45,50% en prevención primaria y el 27,30% en prevención secundaria. El 81,80% de los pacientes con CI son varones. El odds ratio (OR) de presentar CI en los varones frente a las mujeres es 4,97 (1,03–23,93; p=0,03). El OR de presentar CI en los pacientes con historia familiar de ECV prematura es 6,86 (1,32–35,67; p=0,02). Encontramos una asociación estadísticamente significativa entre fumar y el riesgo de ECV (p=0,005) y también entre tener diabetes y el riesgo de ECV (p=0,0001). Si el tratamiento con estatinas se inicia antes de los 40 años, el OR de presentar CI es 6,40 (1,53–26,50; p=0,009). El tiempo medio desde el diagnóstico hasta el evento en el grupo de exfumadores es 10,80±5,80 años y en el grupo de no fumadores es 17,50±2,50 años (p=0,01).

Conclusiones

En nuestra población de referencia con HF, encontramos un mayor riesgo de presentar un evento cardiovascular en los pacientes varones, con antecedentes familiares de ECV prematura, diabéticos y en los que se ha iniciado el tratamiento hipolipidemiante después de los 40 años de edad.

Palabras clave:
Hipercolesterolemia familiar
Factores de riesgo cardiovascular
Enfermedad cardiovascular

Article

These are the options to access the full texts of the publication Clínica e Investigación en Arteriosclerosis (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Clínica e Investigación en Arteriosclerosis (English Edition)

Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.