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Original article
DOI: 10.1016/j.cireng.2018.05.007
1000 Consecutive Liver Transplants. Descriptive Analysis and Evolution of a Single Center
1000 trasplantes hepáticos consecutivos. Análisis descriptivo y evolución de un centro
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José Tinoco González
Corresponding author
tinoko243@hotmail.com

Corresponding author.
, Jose María Álamo Martínez, Carmen Bernal Bellido, Gonzalo Suárez Artacho, Luis Miguel Marín Gómez, Lydia Barrera-Pulido, Javier Padillo Ruíz, Miguel Ángel Gómez Bravo
Unidad de Cirugía Hepatobiliopancreática y Trasplante Hepático, Hospital Universitario Virgen del Rocío, Sevilla, Spain
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Tables (3)
Table 1. Characteristics of Donors and Recipients.
Table 2. Major Clinical Events During Follow-up (25yrs).
Table 3. Causes of Liver Retransplantation by Phases.
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Abstract

Between 1991 and 2013, 1000 liver transplantations were performed at Virgen del Rocio Hospital (Seville, Spain). A retrospective study was conducted, analyzing the characteristics of recipients and donors, indications, surgical technique, complications and survival in 2 different stages (1991–2002 vs 2003–2013) coinciding with the implementation of the MELD scale as a prioritization model. The most frequent indication was of hepatopathy of hepatocellular origin in 48.8%. There was a significant increase in the indications for hepatocarcinoma (8.6% and 24.1% P=.03), and the rate of retransplantation (5.9% vs 9.6%, P=.04). There was a change in the age of donation, going from 27.7 years in 1990 to 62.9 years in 2012 (P=.001). The percentage of patients who did not require blood transfusion doubled (6.16% vs 14.31%, P=.001). Survival of all patients after 1, 5 and 10 years was 77%, 63.5% and 51.3%, respectively.

Keywords:
Liver transplantation
Donation
Survival
Historical series
Seville
Resumen

Desde 1991 a 2013 se realizaron en el Hospital Virgen del Rocío 1.000 trasplantes hepáticos. Se realizó un estudio retrospectivo, en el que se analizaron las características de los donantes y los receptores, las indicaciones, la técnica quirúrgica, las complicaciones y la supervivencia en 2 etapas diferentes (1991-2002 vs 2003-2013), coincidiendo con la implantación del MELD como modelo de priorización. La indicación más frecuente fue la hepatopatía de origen hepatocelular en 48,8%. Hubo un incremento significativo en las indicaciones por hepatocarcinoma (8,6% y 24,1% p=0,03), y de la tasa retrasplantes (5,9% Vs 9,6%, p=0,04). Se apreció un cambio en la edad de donación, pasando de 27,7 años en 1990 a 62,9 años en 2012 (p=0,001). El porcentaje de pacientes que no precisaron transfusión de hemoderivados se duplicó (6,16 vs 14,31%, p=0,001). La supervivencia de todos los pacientes a uno, 5 y 10 años fue del 77, 63,5 y 51,3%, respectivamente.

Palabras clave:
Trasplante hepático
Donación
Supervivencia
Serie histórica
Sevilla

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