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Inicio Cirugía y Cirujanos (English Edition) Triple synchronous primary gynaecological tumours. A case report
Journal Information
Vol. 84. Issue 1.
Pages 69-72 (January - February 2016)
Vol. 84. Issue 1.
Pages 69-72 (January - February 2016)
Clinical case
Open Access
Triple synchronous primary gynaecological tumours. A case report
Tumores triple sincrónicos ginecológicos. Reporte de un caso
Laura Gutiérrez-Palominoa,
Corresponding author

Corresponding author at: C/ La Legión 6-8, 3.° C, 51001 Ceuta, Spain. Tel.: +34 956 51 47 47/686 10 38 47.
, José María Romo-de los Reyesa, María Jesús Pareja-Megíab, José Antonio García-Mejidoa
a Servicio de Ginecología y Obstetricia, Hospital Universitario Virgen de Valme, Sevilla, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Virgen de Valme, Sevilla, Spain
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Tables (1)
Table 1. Diagnostic criteria of synchronous tumours.

Synchronous multiple primary malignancies in the female genital tract are infrequent. From 50 to 70% of them corresponds to synchronous cancers of the endometrium and ovary. To our knowledge, this is only the third case report in the international literature of three concurrent gynaecological cancers of epithelial origin. A case is presented, as well as a literature review due to the infrequency of its diagnosis and the lack of information on the subject.

Clinical case

A 49-year-old woman, with previous gynaecological history of ovarian endometriosis. She underwent a hysterectomy and bilateral oophorectomy, as she had been diagnosed with endometrial hyperplasia with atypia. The final histopathology reported synchronous ovarian, Fallopian tube, and endometrial cancer. An extension study and complete surgical staging was performed, both being negative. She received adjuvant treatment of chemotherapy and radiotherapy. She is currently free of disease.


The aetiology is uncertain. There is controversy relating to increased susceptibility of synchronous neoplasms to pelvic endometriosis and inherited genetic syndromes. Its diagnosis needs to differentiate them from metastatic disease. Additionally, they are problematical from a clinical, diagnostic, therapeutic, and prognostic point of view. The presentation of more cases of triple synchronous cancers is necessary for a complete adjuvant and surgical treatment.

Ovarian cancer
Endometrial cancer
Fallopian tube cancer
Synchronous cancers
Multiple synchronous cancers

El desarrollo sincrónico de múltiples tumores en el tracto genital femenino es infrecuente. Del 50% al 70% lo constituyen el grupo de neoplasias sincrónicas de endometrio y ovario. Para nuestro conocimiento este es el tercer caso de cáncer triple sincrónico ginecológico, de la bibliografía médica internacional. Nos proponemos exponer un caso de nuestra unidad y hacer una revisión de la bibliografía médica de esta entidad, dada la infrecuencia de su diagnóstico y la escasa información al respecto.

Caso clínico

Mujer de 49 años de edad, con historia ginecológica de endometriosis ovárica. Se le realizó histerectomía y anexectomía bilateral, por diagnóstico de hiperplasia endometrial con atipias. La anatomía patológica definitiva informó de neoplasias sincrónicas de ovario, trompa y, endometrio. Se realizó estudio de extensión y se sometió a la paciente a cirugía de estadificación completa, siendo negativas. Se administró quimioterapia y radioterapia adyuvantes. Actualmente se encuentra libre de enfermedad.


La etiología es incierta. Existe controversia acerca de una mayor predisposición de las neoplasias sincrónicas a la endometriosis pélvica y a los síndromes genéticos hereditarios. En su diagnóstico es necesario diferenciarlas de la enfermedad metastásica. Además plantean problemas desde el punto de vista clínico, diagnóstico, terapéutico y pronóstico. Es necesaria la presentación de más casos de neoplasias triple sincrónicas para un tratamiento quirúrgico y adyuvante completo.

Palabras clave:
Cáncer de ovario
Cáncer de endometrio
Cáncer tubular
Neoplasias sincrónicas
Neoplasias sincrónicas múltiples
Full Text

Malignancies which occur in one single subject, simultaneously or successively are termed multiple primary or synchronous tumours, provided they meet the outlined criteria1 (Table 1).

Table 1.

Diagnostic criteria of synchronous tumours.

Each tumour should have a defined pattern of malignancy 
It should be ruled out that one is not the metastasis of the other 
Each tumour presents a different histology, and if both are similar inside the same organ, it should be ensured that no connection between them can be demonstrated. 
Each tumour should follow its natural history and might develop independently 
Each tumour might present with its own symptoms or be a finding during the study required for diagnosis, staging or follow-up of the first, or even only be found post mortem, during autopsy 
Diagnosis of the tumours can be successivea or simultaneousb 




Synchronous tumours affect less than 1–2% of patients affected by cancers of the endometrium and ovary. The prevalence in epithelial cancer of the ovary corresponds to 10%, whereas in the case of adenocarcinoma of the endometrium it corresponds to 5%.2 Tubular adenocarcinomas have an incidence of 1%, most often being diagnosed by chance anatomopathologically following an operation. They generally occur in young, obese, nulliparous and premenopausal women, associated with hypoestrogenism.3 The average age of diagnosis is between the fourth and fifth decades of life.3,4 Some authors have described an association of double and triple synchronous tumours with hereditary genetic mutations, such as Lynch syndrome.5

Clinical case

A 49 year old woman, ex smoker, nulliparous, with a gynaecological history of ovarian endometriosis and a family history of paternal digestive tract tumour and a maternal aunt with breast cancer. An endometrial aspiration biopsy was performed for metrorrhagia. The anatomopathological diagnosis was endometrial hyperplasia with atypias. A scheduled hysterectomy was performed and bilateral adnexectomy. Final histopathology reported synchronous ovarian, right Fallopian tube, and endometrial cancer over extensive areas of ovarian endometriosis and myometrial adenomyosis. No pathological findings were reported in the ovary and contralateral Fallopian tube. The 3 malignancies were visualised without direct connection between them, with a different degree of infiltration. FIGO classification of each of the malignancies was adenocarcinoma of endometrium T1CG2, endometrioid carcinoma of the ovary T1A, and endometrioid adenocarcinoma of the Fallopian tube T1A. Immunohistochemistry revealed the same profile for the 3 malignancies: the presence of positive oestrogen and progesterone receptors, p53 negative and CK7 positive. Thoraco-abdominal computed tomography was requested, with no evidence of distant disease, and the patient underwent full staging surgery, including: peritoneal lavage, omentectomy, appendicectomy, pelvic and paraortic lymphadenectomy. Four and 5 lymph nodes were obtained in the right and left lymph node chains, respectively. At retroperitoneal level 2 lymph nodes were obtained, the anatomopathological study for both was negative. The patient received adjuvant chemotherapy treatment (taxol and cisplatin) and radiotherapy under oncological criteria, given the FIGO stage T1C G2 present in the endometrioid adenocarcinoma, with the objective of reducing the possibility of relapse (Fig. 1).

Figure 1.

Macroscopic image of synchronous triple tumour: endometrium, ovary and Fallopian tube.


The aetiology of synchronous tumours is uncertain. Lauchlan proposed the extended müllerian system, which covers the epithelium from the ovarian surface, Fallopian tubes and uterus (neck and cervix) as a single morphological unit.6 Various authors a posteriori explained the possible presence of receptors in this müllerian system which would respond to carcinogens or hormonal factors.4,7 this would explain synchronous tumours of a similar aetiology, but not those of a different aetiology.

The patients are classically young, obese, nulliparous and premenopausal,3 like the patient presented. There is controversy in medical literature regarding the association of a greater predisposition for synchronous malignancies with pelvic endometriosis.2,8,9 Some authors argue the use of combined hormonal contraception in patients with endometriosis as a chemopreventive factor against gynaecological synchronous malignancies.10

Synchronous carcinomas of the endometrium and ovary pose various problems from a clinical, diagnostic, therapeutic and prognostic perspective; therefore a differential diagnosis with metastatic disease is of crucial importance. In favour of the presence of ovarian metastasis are: the small size of the ovarian lesion, bilateral involvement, pattern of multinodular growth, the presence of associated superficial implants, and prominent vascular lymphatic embolisation of the stroma of the ovary.1,11 Other methods which help us to differentiate synchronous tumours from metastatic tumours are: molecular studies, the presence of micro-satellites, flow cytometry or PTEN oncogene mutation12; although as yet there is no consensus amongst anatomopathologists as to their usefulness.13

Immunohistochemistry is of little value in differentiation, as both endometrioid carcinomas of the ovary and the uterus, primary and metastatic, have similar immunophenotypical characteristics.9

According to Dragoumis et al.14 in their review, treatment should be appropriate for both tumours, taking into consideration that the treatment of one tumour can lead to incomplete treatment of the other. Generally treatment with adjuvant chemotherapy with or without association with radiotherapy is the most used.

Synchronous tumours of the ovary and endometrium are tumours with a good prognosis, especially in the early stages. Survival at 5 years is 85.9% and at 10 years is 80.3%.4,15,16 Survival depends on the FIGO stage, the tumour's histology, and the association with adjuvant treatment.5,15 Relapse varies according to the different authors at around 15.1%4,15 or 34%5 at 5 years.

From an anatomopathological perspective these are tumours of difficult differential diagnosis with metastasis, with different therapeutic and prognostic implications. Studies which enable a differential diagnosis of both are necessary. In general, these are tumours with a good prognosis, as most are diagnosed in early stages and endometrioid histology predominates.


We have only found 2 cases in medical literature on triple synchronous tumours of the ovary, endometrium and Fallopian tube, and therefore we consider that publishing this case is highly relevant. We do not know whether the prognosis and treatment are comparable to synchronous tumours of the ovary and endometrium, or conversely, whether they are more aggressive.

Conflict of interests

The authors have no conflict of interest to declare.

J.L. Gallo, A. González-Paredes, S. López-Criado, M.F. López-Gallego, C. Quiles.
Neoplasias primarias sincrónicas de endometrio y ovario.
Clin Invest Gin Obst, 35 (2008), pp. 35-37
M.M. Alhilli, S.C. Dowdy, A.L. Weaver, St. Sauver, J.L. Keeney, G.L.A. Mariani.
Incidence and factors associated with synchronous ovarian and endometrial cancer: a population-based case–control study.
Gynecol Oncol, 125 (2012), pp. 109-113
P.T. Soliman, B.M. Slomovitz, R.R. Broaddus, C.C. Sun, J.C. Oh, P.J. Eifel, et al.
Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases.
Gynecol Oncol, 94 (2004), pp. 456-462
Y.K. Lim, R. Padma, L. Foo, Y.N. Chia, P. Yam, J. Chia, et al.
Survival outcome of women with synchronous cancers of endometrium and ovary: a 10 year retrospective cohort study.
J Gynecol Oncol, 22 (2011), pp. 239-243
S.K. Ma, H.T. Zhang, Y.C. Sun, L.Y. Wu.
Synchronous primary cancers of the endometrium and ovary: review of 43 cases.
Zhonghua Zhong Liu Za Zhi (Chinese J Oncol), 30 (2008), pp. 690-694
S.C. Lauchlan.
Conceptual unity of the müllerian tumor group. A histological study.
Cancer, 22 (1968), pp. 601-610
M.G. Williams, E.V. Bandera, K. Demissie, L. Rodríguez-Rodríguez.
Syncronous primary ovarian and endometrial cancers: a population-based assessment of survival.
Obstet Gynecol, 113 (2009), pp. 783-789
W.G. McCluggage, N. Wilkinson.
Metastatic neoplasms involving the ovary: a review with an emphasis on morphological and immunohistochemical features.
Histopathology, 47 (2005), pp. 231-247
A. Kondi-Pafiti, D. Grapsa, A. Liapis, K. Papadias, E. Kairi-Vassilatou, D. Hasiakos.
Synchronous ovarian and endometrial carcinoma: a strong link to endometriosis?.
Eur J Gynaecol Oncol, 29 (2008), pp. 256-259
A.M. Kaunitz.
Oral contraceptives and gynecologic cancer: an update for the 1990s.
Am J Obstet Gynecol, 167 (1992), pp. 1171-1176
S. Ferrero, C. Esteve, I. Mora Hervás, J. Sabrià Rius, E. González.
Neoplasias sincrónicas primaria de endometrio y ovario. A propósito de un caso.
E Clín Invest Ginecol Obstet, 34 (2007), pp. 77-79
R. Ricci, P. Komminoth, F. Bannwart, J. Torhorst, E. Wight, P.U. Heitz, et al.
PTEN as a molecular marker to distinguish metastatic from primary synchronous endometrioid carcinomas of the ovary and uterus.
Diag Mol Pathol, 12 (2003), pp. 71-78
A. Caldarella, E. Crocetti, G.L. Taddei, E. Paci.
Coexisting endometrial and ovarian carcinomas: a retrospective clinicopathological study.
Pathol Res Pract, 204 (2008), pp. 643-648
K. Dragoumis, M. Zafrakas, I. Venizelos, D. Kellartzis, T. Mikos, E. Assimakopoulos, et al.
Synchronous primary neoplasm of the uterine corpus and the ovary: a case report.
Eur J Gynaecol Oncol, 25 (2004), pp. 752-754
P.J. Eifel, J. Ross, M. Hendrickson, R.S. Cox, R. Kempson, A. Martinez.
Adenocarcinoma of the endometrium. Analysis of 256 cases with disease limited to the uterine corpus: treatment comparisons.
Cancer, 52 (1983), pp. 1026-1031
R. Zaino, C. Whitney, M.F. Brady, K. DeGeest, R.A. Burger, R.E. Buller.
Simultaneously detected endometrial and ovarian carcinomas – a prospective clinicopathologic study of 74 cases: a Gynecologic Oncology Group Study.
Gynecol Oncol, 83 (2001), pp. 355-362

Please cite this article as: Gutiérrez-Palomino L, Romo-de los Reyes JM, Pareja-Megía MJ, García-Mejido JA. Tumores triple sincrónicos ginecológicos. Reporte de un caso. Cirugía y Cirujanos. 2016;84:69–72.

Copyright © 2015. Academia Mexicana de Cirugía A.C.
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