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Vol. 29. Issue 1.
Materiais 2015
Pages e130-e134 (January - April 2017)
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Vol. 29. Issue 1.
Materiais 2015
Pages e130-e134 (January - April 2017)
DOI: 10.1016/j.ctmat.2016.09.003
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In vitro study of platelet behaviour on titanium surface modified by plasma
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J.O. Vitorianoa, C. Alvesb, D.C. Braza, H.A. Rochab, R.C. Lima da Silvac,
Corresponding author
ruthilima@yahoo.com.br

Corresponding author.
a Posgraduate programme in Mechanical Engineering Department, Federal University of Rio Grande do Norte, Natal, Brazil
b Labplasma, Federal Rural University of Semiarid Region, Mossoró, Brazil
c CTMA, Federal Institute of Rio Grande do Norte, Mossoró, Brazil
Article information
Abstract

Biomedical devices introduced in the human body interact initially with blood cells, their success being dependent on the result of this interaction. This work aimed to obtain optimum biocompatibility and hemocompatibility of the titanium by plasma treatment. For this, discs of commercially pure titanium (CP) were subjected to plasma nitriding using different mixture of nitrogen and hydrogen; the effect of addition of hydrogen to the nitriding plasma was investigated. Before and after treatment, samples were evaluated in terms of topography and wettability using atomic force microscopy and sessile drop tests, respectively. The titanium biological response was evaluated in vitro through the application of platelet-rich plasma (PRP) on the surfaces modified and analysis of their behaviour from the point of view of surface tension and cell adhesion. Surface properties, such as roughness and wettability, were sensitive to the hydrogen/nitrogen ratio in the nitriding plasma, suggesting a strategy for producing different surfaces of biomedical devices. Results showed to be possible to obtain surfaces with different response to the adhesion of platelets, covering different applications.

Keywords:
Biocompatibility
hemocompatibility
titanium
plasma treatment
biological response
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Copyright © 2017. Portuguese Society of Materials (SPM)
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