Buscar en
Ciência & Tecnologia dos Materiais
Toda la web
Inicio Ciência & Tecnologia dos Materiais Competitiveness of chitosan-based implants
Journal Information
Vol. 26. Issue 2.
Pages 77-88 (July - December 2014)
Download PDF
More article options
Vol. 26. Issue 2.
Pages 77-88 (July - December 2014)
Full text access
Competitiveness of chitosan-based implants
Nuno Guitian Oliveiraa,b,c,
Corresponding author

Corresponding author.
, Luís F.V. Pintob, Luís Reisa, Alexandra Rodriguesa,d
a ICEMS, Instituto Superior Técnico, University of Lisbon, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
b Altakitin S.A., Rua José Gomes Ferreira, Arm. D, 2660-360 São Julião do Tojal, Lisboa, Portugal
c MIT Portugal Program, IST-Tagus Park, Av. Professor Cavaco Silva, 2744-016 Porto Salvo, Portugal
d GI-MOSM, Instituto Superior de Engenharia de Lisboa, ISEL, Rua Conselheiro Emídio Navarro, 1959-007 Lisboa, Portugal
This item has received
Article information

Biomaterials have been extensively developed and applied in medical devices. Among these materials, bioabsorbable polymers have attracted special attention for orthopedic applications where a transient existence of an implant can provide better results, when compared with permanent implants. Chitosan, a natural biopolymer, has generated enormous interest due to its various advantages such as biocompatibility, biodegradability and osteoconductive properties. In this paper, an assessment of the potential of a developed innovative production process of 3D solid and dense chitosan-based products for biomedical applications is performed and presented. Therefore, it starts with a brief explanation of the technology, highlighting its main features. Then, several potential applications and their markets were identified and assessed. After choosing a primary application and market, its potential as well as its uncertainties and risks were identified. A business model suggesting how to materialize the value from the application was sketched. After that, a brief description of the market as well as the identification of the main competitors and their distinctive features was made. The supply chain analysis and the go-to-market strategy were the following steps. In the end, a final recommendation based on the assessment of the information was prepared.

bioabsorbable implants
orthopedic applications
go-to-market strategy.
Full text is only aviable in PDF
H. Park, J.S. Temenoff, A.G. Mikos, in: F. Bronner, M.C. Farach-Carson, A.G. Mikos (Eds.), Engineering of Functional Skeletal Tissues, Springer London, 2007, pp. 55-68.
J.M. Anderson.
J Mater. Sci. Mater. Med, 17 (2006), pp. 1025
R. Langer, J.P. Vacanti.
Science, 260 (1993), pp. 920
T. Chandy, C.P. Sharma.
Biomater. Artif. Cells Artif. Organs, 18 (1990), pp. 1
MarketsandMarkets, Biomaterials Market [By Products (Polymers, Metals, Ceramics, Natural Biomaterials) & Applications (Cardiovascular, Orthopedic, Dental, Plastic Surgery, Wound Healing, Tissue Engineering, Ophthalmology, Neurology Disorders)] – Global Forecasts to 2017,, 2013.
P.F. Drucker.
Harv. Bus. Rev, 76 (1998), pp. 149
C. Gardner, T. Acharya, D. Yach.
Health Aff, 26 (2007), pp. 1052
E. Khor, L.Y. Lim.
Biomaterials, 24 (2003), pp. 2339
NCBI, Literature, PubMed, in:
N. Guitian Oliveira, A. Rodrigues, L. Reis, L.F.V. Pinto.
J. Chitin Chitosan Sci, 1 (2013), pp. 210
N. Guitian Oliveira, T. Sirgado, L. Reis, L.F.V. Pinto, C.L. da Silva, F.C. Ferreira, A. Rodrigues.
J. Mech. Behav. Biomed. Mater, 40 (2014), pp. 413
A.W. Ulwick.
Harv. Bus. Rev, 80 (2002), pp. 91
J.L. Bower, C.M. Christensen.
Harv. Bus. Rev, 73 (1995), pp. 43
Q. Ao, C.-K. Fung, A.Y.-P. Tsui, S. Cai, H.-C. Zuo, Y.-S. Chan, D.K.-Y. Shum.
K. Haastert-Talini, S. Geuna, L.B. Dahlin, C. Meyer, L. Stenberg, T. Freier, C. Heimann, C. Barwig, L.F.V. Pinto, S. Raimondo, G. Gambarotta, S.R. Samy, N. Sousa, A.J. Salgado, A. Ratzka, S. Wrobel, C. Grothe.
J.K. Suh, H.W. Matthew.
Biomaterials, 21 (2000), pp. 2589
J.P. Wilkerson, J.E. Zvijac, J.W. Uribe, M.R. Schürhoff, J.B. Green.
J. Shoulder Elbow Surg, 12 (2003), pp. 117
W. Ciccone, C. Motz, C. Bentley, J. Tasto.
J. Am. Acad. Orthop. Surg, 9 (2001), pp. 280
Experts I 2011 Orthopedic Implants: A Global Market Overview 197.
MarketsandMarkets, Orthopedic Devices Market (Forecast to 2016),, 2011.
MarketsandMarkets, Global Spinal Implants and Surgical Devices Market - by Technology (Spinal Fusion & Fixation, Non-Fusion, Spinal Decompression, Vertebral Compression Fracture Repair & Spine Biologics), by Products - Trends, Competitive Analysis & Forecasts till 2017,, 2012.
A.L. Williams, M.F. Gornet, J.K. Burkus.
AJNR Am. J. Neuroradiol, 26 (2005), pp. 2057
T. Taylor, Spine, InnerBody, in:
W. Koeller, S. Muehlhaus, W. Meier, F. Hartmann.
J. Biomech, 19 (1986), pp. 807
F. Costa, M. Sassi, A. Ortolina, A. Cardia, R. Assietti, A. Zerbi, M. Lorenzetti, F. Galbusera, M. Fornari.
Eur. Spine J, 20 (2011), pp. S46
Spine Center, Fusion with Interbody Cages, University of Maryland Medical Center, 2013.
R.W. Haid, C.L. Branch, J.T. Alexander, J.K. Burkus.
P.F. Ullrich Jr, Spine-health, in: http://www.spine- fusion (2004).
R.A. Deyo, D.T. Gray, W. Kreuter, S. Mirza, B.I. Martin.
Spine, 30 (2005), pp. 1441
H. Kang, S.J. Hollister, F. La Marca, P. Park, C.-Y. Lin.
J. Biomech. Eng, 135 (2013), pp. 1
Y.-S. Kim.
Clin. Neurol. Neurosur, 99 (1997), pp. S108
C. Benjamin Ma, Spinal fusion, U.S. National Library of Medicine, 2013.
J.-Y. Ding, S. Qian, L. Wan, B. Huang, L.-G. Wang, Y. Zhou.
Arch. Orthop. Trauma Surg, 130 (2010), pp. 565
R.C. Sasso, SpineUniverse, in: ical/thoracic/screws-cages-or-both, 2012.
P.F. Ullrich Jr, Spine-health, in: http://www.spine- (2010).
Rothman Institute, in: on-for-cervical-thoracic-and-lumbar-trauma.
F. Galbusera, H. Schmidt, H.-J. Wilke.
Eur. Spine J, 21 (2012), pp. 455
G. Matgé, T. a Leclercq.
Acta Neurochir, 142 (2000), pp. 425
Medical Multimedia Group, LLC, in: fusion/topic/167.
R.C. Sasso, SpineUniverse, in: ogy/surgical/lumbar/biomechanics-lumbosacral-fusion, 2012.
J.D. Coe.
Neurosurg. Focus, 16 (2004), pp. 31S
D. Bludovsky, M. Choc.
Eur. Cell. Mater, 11 (2006), pp. 33
T. Kokubo, H.-M. Kim, M. Kawashita.
Biomaterials, 24 (2003), pp. 2161
F. El Masri, E. Sapin de Brosses, K. Rhissassi, W. Skalli, D. Mitton.
Comput. Methods Biomech. Biomed. Engin, 15 (2012), pp. 23
European Commission, Medical Devices, in: devices/faq/market_en.htm.
[46], in:
A. Osterwalder, Y. Pigneur, A. Smith.
Business Model Generation.
1st Ed, Wiley, (2010),
Strategyzer AG, The Business Model Canvas, in:
K. Ulrich, S.D. Eppinger.
Product Design and Development.
3rd ed., McGraw-Hill, (2003),
American Academy of Orthopaedic Surgeons, in:, 2010.
Zimmer, BAK/C® Anterior Cervical Interbody Fusion System, in: professionals/products/spine/bak-anterior-cervical- interbody-fusion.html
Stryker, Ray Threaded Fusion Cage, in: home/st_pag_detailed-product-info/st_pag_spinal- implants/eu_pag_spine-interbody/eu_pag_spine-ray- threaded-fusion-cage.htm.
T.A. Zdeblick, J.K. Burkus, LT-CAGE Lumbar Tapered Fusion Device, Medtronic Sofamor Danek, USA, 2000.
Medtronic, Infuse Bone Graft/LT-Cage Lumbar Tapered Fusion Device, in: healthcare-professionals/products-therapies/spinal/bone- graft-options/infuse-bone-graft/, 2010.
U.S. National Institutes of Health, in:
P.W. Pavlov, M. Spruit, M. Havinga, P.G. Anderson, J. van Limbeek, W.C. Jacobs.
Eur. Spine J, 9 (2000), pp. 224
[57], Medtronic Infuse Bone Graft Hot Leg. Issues, 2014.
R.D. Dickerman, A.S. Reynolds, B. Morgan.
Int. Orthop, 32 (2008), pp. 717
P.F. Ullrich Jr, Spine-health, in: http://www.spine- a-tissue-bank (2009).
C.G. Ambrose, T.O. Clanton.
Ann. Biomed. Eng, 32 (2004), pp. 171
P.I.J.M. Wuisman, T.H. Smit.
Eur. Spine J, 15 (2006), pp. 133
D. Mukherjee, W. Pietrzak.
J. Craniofac. Surg, 22 (2011), pp. 679
C.R. Lippman, M. Hajjar, B. Abshire, G. Martin, R.W. Engelman, D.W. Cahill.
Neurosurg. Focus, 16 (2004), pp. E4
A.R. Vaccaro, K. Singh, R. Haid, S. Kitchel, P. Wuisman, W. Taylor, C. Branch, S. Garfin.
Spine J, 3 (2003), pp. 227
M. van Dijk, T.H. Smit, S. Sugihara, E.H. Burger, P.I. Wuisman.
Spine, 27 (2002), pp. 682
J.D. Coe, A.R. Vaccaro.
Spine, 30 (2005), pp. S76
J.Y. Lazennec, A. Madi, M. a Rousseau, B. Roger, G. Saillant.
Eur. Spine J, 15 (2006), pp. 1545
M.A. Slivka, D.B. Spenciner, H.B. Seim, W.C. Welch, H.A. Serhan, A.S. Turner.
T.H. Smit, T.A. Engels, P.I.J.M. Wuisman, L.E. Govaert.
A. Smith, M. Arginteanu, A. Steinberger, M. Camins.
Spine J, 10 (2010), pp. 94S
T.U. Jiya, T. Smit, B.J. van Royen, M. Mullender.
Eur. Spine J, 20 (2011), pp. 618
T.H. Smit, T. a P. Engels, S.H.M. Söntjens, L.E. Govaert.
J. Mater. Sci. Mater. Med, 21 (2010), pp. 871
F. Kandziora, R. Pflugmacher, M. Scholz, T. Eindorf, K.J. Schnake, N.P. Haas.
Spine, 29 (2004), pp. 1845
D.W. Cahill, G.J. Martin, M.V. Hajjar, W. Sonstein, L.B. Graham, R.W. Engelman.
J. Neurosurg. Spine, 98 (2003), pp. 195
M. van Dijk, T.H. Smit, M.F. Arnoe, E.H. Burger, P.I. Wuisman.
Eur. Spine J, 12 (2003), pp. 34
Y. Shikinami, M. Okuno.
Biomaterials, 24 (2003), pp. 3161
N. Maniadakis, A. Gray.
J. Bone Joint Surg. Br, 82 (2000), pp. 2
Symmetrics Group, A Go-To-Market Strategy Primer, in: primer/, 2012.
W.A. Sahlman.
Harv. Bus. Rev, 75 (1997), pp. 98
R.P. Patel, A Patent Portfolio Development Strategy for Start-Up Companies, Fenwick & West LLP, USA, 2002.
M.J. Shuster, H. Su, S. Blaug.
Nat. Biotechnol, 21 (2003), pp. 701
D.S. Couto, L. Perez-Breva, P. Saraiva, C.L. Cooney.
Adv. Drug Deliv. Rev, 64 (2012), pp. 69
Copyright © 2015. Sociedade Portuguesa de Materiais (SPM)
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos