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Vol. 15. Issue 4.
Pages 178-180 (October - December 1979)
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Vol. 15. Issue 4.
Pages 178-180 (October - December 1979)
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Fibrosis pulmonar secundaria a la administracion de ciclofosfamida
Pulmonary fibrosis secondary to the administration of cyclop-hosphamide
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J. Morera, X. Formiguera, A. Aranda, F. Morell, S. Sendra
Departamento de Medicina (Dr. J. Tornos) Sección de Neumología. Residencia Sanitaria «Francisco Franco». Barcelona
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Resumen

Los autores publican un caso de fibrosis pulmonar por ciclofosfamida en un paciente con leucemia linfoide crónica. La FP apareció al cabo de diez años de administración del fármaco y no progresó con la retirada del mismo. El diagnóstico se realizó por biopsia transbronquial y la exclusión de otros procesos. Los autores revisan la literatura sobre el tema e insisten en que los criterios para incluir un caso de FP como secundaria a ciclofosfamida deben ser rigurosos al máximo.

Summary

The authors publish a case of pulmonary fibrosis by cyclophosphamide in a patient with chronic lymphoid leukemia. The pulmonary fibrosis appeared after ten years of administration of the drug and did not progress when the drug was retired. Diagnosis was made by transbronchial biopsy and the exclusion of other processes. The authors review the medical bibliography on this topic and insist that the criteria for including a case of pulmonary fibrosis as secondary to cyclophosphamide must be rigorous in the extreme.

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Bibliografia
[1.]
A.R. Patel, P.C. Shah, H.L. Rhee, K.P. Rao.
Cyclophosphamide therapy and interstitial pulmonary Fibrosis.
Cancer, 38 (1976), pp. 1542
[2.]
R. Andre, H. Rochant, B. Dreyfus, G. Duchamel, J. Pechere.
Fibrose interstitielle diffuse du poumon au cours d’une maladie de Hodgkin traitée par des doses elévées d’endoxan.
Bull Soc. Med. Hop., 118 (1967), pp. 147
[3.]
A.E. Rodin, M.E. Haggard, L.B. Travis.
Lung changes and chemotherapeutic agents in chidhood.
Am. J. Dis. Child., 120 (1970), pp. 337
[4.]
V.A. Dohner, H.P. Ward, R.E. Standard.
Alveolitis during procarbazine, vincristine and cyclophosphamide Therapy.
Chest., 62 (1972), pp. 636
[5.]
A.A. Topillow, S.P. Rothenberg, T.S. Cottrell.
Interstitial pneumonia after prolonged treatment with cyclophosphamide.
Chest, (1973), pp. 64-720
[6.]
G.J. Mark, A. Lehimgar-Zadeh, B.D. Ragsdale.
Cyclophosphamide pneumonitis.
Thorax, 33 (1978), pp. 89
[7.]
D.A. Karnofsky.
Late effects of im-munosuppressive anticancer drugs.
Fed. Proc., 26 (1967), pp. 925
[8.]
I. Meschan, C.R. De armas, M. Scharyj.
Adult bronchopulmonary displasia. The similarity in roentgen and histopathologic appearancebetween some cases of oxygen toxicity, radiation pneumonitis, and postcytotoxic nonspecific bronchopneumonia.
Radiology, 92 (1969), pp. 612
[9.]
E.C. Rosenow.
The spectrum of druginduced pulmonary disease.
Ann. Intern. Med., 77 (1972), pp. 977
[10.]
Case records of the Massachusetts General Hospital (Caso 26/1972).
N. Engl. J. Med., 286 (1972), pp. 1405
[11.]
F.H. Stutz, D.C. Tormey, J. Bloom.
Nonbacterial pneumonitis with multidrug antineoplastic therapy in breast carcinoma.
Can. Med. Assoc. J., 108 (1973), pp. 710
[12.]
Case Records of the Massaehusetts General Hospital (Caso 12/1978).
N. Engl. J. Med., 298 (1978), pp. 729
[13.]
H.D. Sostman, R.A. Matthay, C.E. Putman.
Cytotoxic drug-induced lung di sease.
Am. J. Med., 62 (1977), pp. 608
[14.]
P.S. Schein, S.H. Winokur.
Immunosuppresive and cytotoxic chemotherapy: long term complications.
Ann. Intern. Med., 82 (1975), pp. 84
[15.]
B.M. Nelson, G.A. Andres.
Breast cancer and cytologic dysplasia in many organs after busulfan.
Am. J. Clin. Pathol., 42 (1964), pp. 37
[16.]
W.A. Littler, C. Ogilvie.
Lung function in patients receiving busulfan.
Br. Med. J., 4 (1970), pp. 530
[17.]
M.L. Feingold, L.G. Koss.
Ef fects of long-term administration of busulfan.
Arch. Intern. Med., 124 (1969), pp. 66
[18.]
B.C. Korbitz, C.W. Reiquam.
Busulfan in chronic granulocytic leukemia. A spectrum of clinical considerations.
Clin. Med., 76 (1969), pp. 16
[19.]
H. Oliner, R. Schwartz, F. Rubino, W. Dameshek.
Interstitial pulmo nary fibrosis following busulfan therapy.
Am. J. med., 31 (1961), pp. 134
[20.]
H. Stott, R. Stephens, W. Fox, G. Simon, D.C. Roy.
An investigation of the chest radiographs in a controlled trial of busulfan, cyclophosphamide and a placebo after resention for carcinoma of the lung.
Thorax, 31 (1976), pp. 265
[21.]
R.K. Brynes, S.H. Mostafaviopour, J.J. Hennessy, D. Variakojis.
Diagnosis of busulfan lung by transcatheter biopsy.
Chest, 64 (1973), pp. 771
[22.]
P.Y. Holoye, M.A. Luna, B. Mackay, C.W.M. Bedrossian.
Bleomycin hypersensititivity pneumonitis.
Ann. Inl. Med., 88 (1978), pp. 47
Copyright © 1979. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
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