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Vol. 21. Issue 5.
Pages 241-244 (September - October 1985)
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Vol. 21. Issue 5.
Pages 241-244 (September - October 1985)
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Efecto broncodilatador de los antiinflamatorios no esteroideos en el asma. Comunicacion de un caso
Bronchodilating effect of non-steroid anti-inflammatories in asthma. One case
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F. Sanchez-Toril, L. Prieto, J. Palop, M. Juyol, A. Paricio, J. Castro
Sección de Alergia. Servicio de Medicina Interna. Hospital Dr. Peset. Valencia
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Se describe un caso de rinosinusitis hiperplásica y asma bronquial intrínseco en el que diferentes analgésicos (dipirona, paracetamol, aspirina, indometacina, naproxen) mostraron efecto broncodilatador, que se objetivó mediante valoración funcional respiratoria antes y en diferentes momentos después de administrar cada fármaco. Es éste el 9.° enfermo comunicado hasta la actualidad con esta especial susceptibilidad a la acción de los analgésicos en sus vías aéreas y el primero en el que se ha objetivado la existencia de poliposis nasal y efecto broncodilatador con el paracetamol. Algunos de los rasgos clínicos encontrados en la paciente apoyan la hipótesis de que el efecto beneficioso de los analgésicos pudiera ser transitorio y que estos fármacos desencadenarían broncospasmo en un momento dado.

The authors describe a patient with hyperplasic rhino-sinusitis and intrinsic bronchial asthma with whom difierent analgesics (dipirone, paracetamol, aspirine, indo-methacin, naproxen) had a bronchodilating effect demonstrated through respiratory function tests before and at different moments following administration of each drug. To the authors knowledge this is only the 9th case documented with this particular susceptibility of the airways to these anaigesics and the first case with nasal polyposis and a bronchodilating effect of paracetamol.

Some of the clinical features of this patient support the hypothesis that the beneficial effect of these analgesics may be only transient and that the drugs will trigger bronchospasms at certain moments.

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Bibliografia
[1.]
M. Samter, R.F. Beers.
Intolerance to aspirin. Clinical studies and consideration of its pathogenesis.
Ann Intern Med, 68 (1968), pp. 975-976
[2.]
G.A. Settipane, F.H. Chafee, D.E. Klein.
Aspirin intolerance II. A prospective study in an atopic and normal population.
J Allergy Clin Immunol, 53 (1974), pp. 200-204
[3.]
G.S. Rachelefsky, A. Coulion, S.C. Siegel, E.R. Stiehm.
Aspirin intolerance in chronic childhood asthma: detected by oral challenge.
Pediatrics, 56 (1975), pp. 443-448
[4.]
J.R. McDonald, P.A. Mathison, D.D. Stevenson.
Aspirin intolerance in asthma, detection by oral challenge.
J Allergy Clin Immunol, 50 (1972), pp. 198-201
[5.]
J.C. Delaney.
The diagnosis of aspirin idiosyncrasy by analgesic challenge.
Clin Allergy, 6 (1976), pp. 177-181
[6.]
R.W. Weber, M. Hoffman, D.A. Raine, H.S. Nelson.
Incidence of bronchoconstriction due to aspirin, azo dyes, non-azodyes and preservatives in a population of perennial asthmatics.
J Allergy Clin Immunol, 64 (1979), pp. 32-37
[7.]
S.L. Spector, C.H. Wangaard, R.S. Farr.
Aspirin and concomitant idiosyncrasies in adult asthmatic patients.
J Allergy Clin Immunol, 64 (1979), pp. 500-506
[8.]
S.M. Stenius, M. Lemola.
Hipersensitivity to acetylsalicylic acid (ASA) and tartrazine in patients with asthma.
Clin Allergy, 6 (1976), pp. 119-129
[9.]
A. Basomba, A. Pomar, A. Peláez, I.G. Villalmanzo, A. Campos.
The effect of sodium cromoglycate in preventing aspirin induced bronchospasm.
Clin Allergy, 6 (1976), pp. 269-275
[10.]
S.L. Spector, R.S. Farr.
Aspirin idiosyncrasy: asthma and urticaria.
Principies and practice, pp. 1249-1273
[11.]
R.F. Lockey, D.L. Rucknagel, N.A. Vanselow.
Familial occurrence of asthma, nasal polyps and aspirin intolerance.
Ann Intern Med, 78 (1973), pp. 57-63
[12.]
D. Kordansky, N.F. Adkinson, P.S. Norman, R.R. Rosenthal.
Asthma improved by nonesteroidal anti-inflamatory drugs.
Ann Intern Med, 88 (1978), pp. 508-511
[13.]
A. Szczeklik, R.J. Gryglewski, E. Nizankowska.
Asthma relieved by aspirin and by other cyclo-oxygenase inhibitors.
Thorax, 33 (1978), pp. 664-665
[14.]
A. Szczeklik, E. Nizankowska.
Asthma improved by aspirin-like drugs.
Br J Dis Chest, 77 (1983), pp. 153-158
[15.]
A. Szczeklik, R.J. Glyglewski, G. Czerniawska-Mysic.
Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients.
Br Med J, 1 (1975), pp. 67-68
[16.]
J.R. Vane.
The mode of action of aspirin and similar compounds.
J Allergy Clin Immunol, 58 (1976), pp. 691-704
[17.]
K.J. Stone, S.J. Mather, P.P. Gibson.
Selective inhibition of prostaglandin biosynthesis by gold salts and phenylbutazone.
Prostaglandins, 10 (1975), pp. 241-245
[18.]
R. Flower, J. Vane.
Inhibition of prostaglandin synthesis in brain explains the anti-pyretic activity of parecetamol.
Nature, (1972), pp. 240-244
[19.]
R.S. Farr, S.L. Spector, C. Wangaard.
Asthma and nonsteroidal antiinflamatory drugs.
Ann Intern Med, 89 (1978), pp. 577
Copyright © 1985. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
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