Special Issue on Genomic Medicine in Obesity and Chronic Liver Damage
Edited by Sonia Roman
Obesity is a complex disease comprising multiple genetic and environmental factors causing important metabolic dysfunctionalities in body organs including the liver. Currently, the aim is to provide personalized medicine and nutrition strategies to detect, manage and treat obesity-related liver damage at earlier stages and avoid end-stage liver disease. Basic and clinical research are needed to guide and reinforce the capacities of regional health care systems to respond according to the biological characteristics of the population.
Based on the Aim and Scope of Annals of Hepatology, we enthusiastically announce our Special Issue "Obesity and Liver Damage" for authors to contribute with original articles and reviews. We welcome studies focusing on strategies for early detection, prevention, medical or nutritional therapies using "omics" methodologies either accessed exclusively or in combination with lifestyle factors (diet, physical activity, mental health). Large cohort prospective/retrospective epidemiological studies could be considered. We hope that these contributions aid in increasing our insights on the prevention of obesity and chronic liver damage in populations of Latin America and other regions around the world.
Keywords: Obesity, liver damage, insulin resistance, NAFLD, inflammation, fibrosis, cirrhosis, lifestyle factors.
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Variants in olfactory receptor genes are highly enriched in Mexican extreme obese/NASH patients
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Mexican extreme obese/NASH patients present genetic susceptibility to developing liver cancer
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Identifying genetic susceptibility to extreme obesity/NASH might facilitate the implementation of precision medicine