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Inicio Allergologia et Immunopathologia Future prospect of faecal microbiota transplantation as a potential therapy in a...
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Vol. 46. Issue 3.
Pages 307-309 (May - June 2018)
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Vol. 46. Issue 3.
Pages 307-309 (May - June 2018)
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DOI: 10.1016/j.aller.2017.04.008
Future prospect of faecal microbiota transplantation as a potential therapy in asthma
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Y. Kanga,b,
Corresponding author
657151276@qq.com

Corresponding author.
, Y. Caia,c
a Medical School, Kunming University of Science and Technology, Kunming, Yunnan, China
b Genetics and Pharmacogenomics Laboratory, Kunming University of Science and Technology, Kunming, Yunnan, China
c Pathogen Biology Laboratory, Kunming University of Science and Technology, Kunming, Yunnan, China
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Received 17 March 2017. Accepted 20 April 2017
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Abstract

There is convincing evidence from both human and animal studies suggesting that the gut microbiota plays an important role in regulating immune responses associated with the development of asthma. Certain intestinal microbial strains have been demonstrated to suppress or impair immune responsiveness in asthma experimental models, suggesting that specific species among gut commensal microbiota may play either a morbific or phylactic role in the progression of asthma. Evidence to date suggests that the intestinal microbiota represent fertile targets for prevention or management of asthma. The faecal microbiota transplantation (FMT) is a rather straightforward therapy that manipulates the human gastrointestinal (GI) microbiota, by which a healthy donor microbiota is transferred into an existing but disturbed microbial ecosystem. The FMT may therefore represent a therapeutic approach for asthma treatment in the foreseeable future. At present, FMT therapy for asthma is very limited and should be actively studied. Considerable efforts are needed to increase our knowledge in the field of FMT therapy for asthma. In this review, we aimed to provide several insights into the development of FMT therapy for asthma.

Keywords:
Gut microbiota
Faecal microbiota transplantation
FMT
Asthma
Probiotics/prebiotics

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