Buscar en
Allergologia et Immunopathologia
Toda la web
Inicio Allergologia et Immunopathologia Wheezing and risk factors in the first year of life in Cantabria, Spain. The EIS...
Journal Information
Vol. 43. Issue 6.
Pages 543-552 (November - December 2015)
Download PDF
More article options
Vol. 43. Issue 6.
Pages 543-552 (November - December 2015)
Original Article
DOI: 10.1016/j.aller.2014.09.001
Wheezing and risk factors in the first year of life in Cantabria, Spain. The EISL study
A. Bercedo-Sanza,
Corresponding author

Corresponding author.
, L. Lastra-Martínezb, J. Pellegrini-Belinchónc, E. Vicente-Galindod, F. Lorente-Toledanoe, L. García-Marcosf
a Primary Care Pediatrician, Centro de Salud Buelna, Los Corrales de Buelna, Spain
b Primary Care Pediatrician, Centro de Salud Cudeyo, Rubayo, Spain
c Primary Care Pediatrician, Centro de Salud de Pizarrales, Salamanca, Spain
d Department of Statistics, University of Salamanca, Spain
e Department of Pediatrics, University of Salamanca, Spain
f Unit of Pediatric Pneumology and Allergy, “Virgen de la Arrixaca” University Children's Hospital, University of Murcia, Spain
Article information
Full Text
Download PDF
Figures (1)
Tables (4)
Table 1. Study subjects. Descriptive results.
Table 2. Descriptive results in the infants who have presented wheezing.
Table 3. Wheezing risk factors. Odds ratio (OR) with 95% confidence interval (95%CI).
Table 4. Recurrent wheezing (RW) risk factors. Odds ratio (OR) with 95% confidence interval (95%CI).
Show moreShow less

To determine the prevalence of wheezing during the first year of life in Cantabria, Spain and its associated risk factors.


A cross-sectional, multicentre, descriptive epidemiological study was carried out in a representative sample of 958 infants in the first year of life, born in Cantabria. A previously validated and standardised written questionnaire was completed by the parents of infants seen between 12 and 15 months of age in the Primary Care Centres.


The prevalence of wheezing was 32.7%. A relationship was found with male gender (OR 1.38, 95%CI [1.05–1.81]), the presence of a sibling (OR 2.43 [1.38–3.98]), attending nursery school (OR 2.40 [1.71–3.35]), exclusive breastfeeding for <3 months (OR 1.47 [1.12–1.93]), a first cold at ≤3 months (OR 2.07 [1.56–2.74]), asthma in siblings (OR 2.17 [1.25–3.77]), parental allergic rhinitis (OR 1.62 [1.10–2.37]) and paracetamol use >1 a week (OR 2.49 [1.31–4.73]), and maternal smoking during pregnancy (OR 2.18 [1.51–3.15]). The prevalence of recurrent wheezing (≥3 episodes) was 14.3%. Significant associations were observed with the male gender (OR 1.79 [1.23–2.60]), attending nursery school (OR 2.92 [1.96–4.35]), first cold at ≤3 months (OR 2.11 [1.46–3.04]), eczema (OR 1.92 [1.21–3.04]), maternal asthma (OR 1.77 [1.00–3.14]), exclusive breastfeeding for <3 months (OR 1.53 [1.06–2.22]), and maternal smoking during pregnancy (OR 1.53 [1.05–2.22]).


One third of the infants experienced wheezing during the first year of life; those who were less exclusively breastfed, attended nursery school, presented eczema, family asthma or allergic rhinitis, and maternal smoking during pregnancy.

Wheezing in infants
Recurrent wheeze


These are the options to access the full texts of the publication Allergologia et Immunopathologia

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Allergologia et Immunopathologia

Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.