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Journal Information
Vol. 44. Issue 6.
Pages 571-579 (November - December 2016)
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Vol. 44. Issue 6.
Pages 571-579 (November - December 2016)
Original Article
DOI: 10.1016/j.aller.2016.05.003
Variations of B cell subpopulations in peripheral blood of healthy Mexican population according to age: Relevance for diagnosis of primary immunodeficiencies
L. Berrón-Ruíza,b, G. López-Herrerab, C.E. Ávalos-Martínezc,, C. Valenzuela-Poncea, E. Ramírez-SanJuand, G. Santoyo-Sáncheze, F. Mújica Guzmánf, F.J. Espinosa-Rosalesb, L. Santos-Argumedoa,
Corresponding author

Corresponding author.
a Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados-IPN, México, D.F., Mexico
b Unidad de Investigación en Inmunodeficiencias, Instituto Nacional de Pediatría-SSa, México, D.F., Mexico
c Laboratorio de Inmunoquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F., Mexico
d Laboratorio de Farmacología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F., Mexico
e Programa de Posgrado en Ciencias Médicas, Odontológicas y de la Salud, Universidad Nacional Autónoma de México, México, D.F., Mexico
f Laboratorio de Hematología, Instituto Nacional de Pediatría-SSa, México, D.F., Mexico
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Figures (3)
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Tables (4)
Table 1. Ages and genders of the populations under study.
Table 2. Total numbers of lymphocytes and B cells according to age.
Table 3. Percentages of B cell subpopulations in healthy donors according to age.
Table 4. Absolute numbers of B cell subpopulations in healthy donors according to age.
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Additional material (1)

Peripheral blood B cells include lymphocytes at various stages of differentiation, each with a specific function in the immune response. All these stages show variations in percentage and absolute number throughout human life. The numbers and proportions of B subpopulation are influenced by factors such as gender, age, ethnicity, and lifestyle. This study establishes reference values according to age of peripheral blood B cell subtypes in healthy Mexican population.


Peripheral blood from healthy new-borns and adults were analysed for total B cell subpopulations, using surface markers such as CD19, IgM, IgD, CD21, CD24, CD27, and CD38, to identify naïve, memory with and without isotype switch, double-negative, transitional, and plasmablast cells.


We observed a significant variation in terms of frequency and absolute counts between all groups analysed. Values from each B cell subpopulation show variations according to age.


In order to attempt to elucidate reference values for B cell subpopulation, the present study evaluated a population sample of healthy blood donors from this region. Values reported here can also be used as a tool for diagnosis of diseases in which B cell maturation is affected.

Transitional B cells
Naïve B cells
Memory B cells
Subpopulation B cells


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