Regístrese
Buscar en
Allergologia et Immunopathologia
Toda la web
Inicio Allergologia et Immunopathologia Utility of bronchodilator response for asthma diagnosis in Latino preschoolers
Journal Information
Vol. 42. Issue 6.
Pages 553-559 (November - December 2014)
Share
Share
Download PDF
More article options
ePub
Vol. 42. Issue 6.
Pages 553-559 (November - December 2014)
Original Article
DOI: 10.1016/j.aller.2014.02.004
Utility of bronchodilator response for asthma diagnosis in Latino preschoolers
Visits
642
M. Linares Passerinia,
Corresponding author
m.linares@manquehue.net

Corresponding author.
, R. Meyer Peiranoa, I. Contreras Estaya, I. Delgado Becerrab, J.A. Castro-Rodriguezc
a Pediatric Respiratory Section, Hospital Padre Hurtado, Santiago, Chile
b Faculty of Medicine Clínica Alemana Universidad del Desarrollo, Santiago, Chile
c Departments of Pediatrics and Family Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
This item has received
642
Visits
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (1)
Tables (4)
Table 1. Demographic characteristics of healthy controls and asthmatics preschoolers. Data shown as mean (DS or range) for continuous and n (%) for categorical variables.
Table 2. Characteristics of the spirometry variables in controls and asthmatics preschoolers. CV: coefficient of variation.
Table 3. Spirometric values and bronchodilator response (calculated as percentage of change from basal value).
Table 4. Sensitivity, specificity and positive likelihood ratio (+LR) of bronchodilator response (calculate as % of change from basal) using ROC (receiver operating curve).
Show moreShow less
Abstract
Background

Asthma diagnosis in preschoolers is mostly based on clinical evidence, but a bronchodilator response could be used to help confirm the diagnosis. The objective of this study is to evaluate the utility of bronchodilator response for asthma diagnosis in preschoolers by using spirometry standardised for this specific age group.

Methods

A standardised spirometry was performed before and after 200mcg of salbutamol in 64 asthmatics and 32 healthy control preschoolers in a case-control design study.

Results

The mean age of the population was 4.1 years (3–5.9 years) and 60% were females. Almost 95% of asthmatics and controls could perform an acceptable spirometry, but more asthmatics than controls reached forced expiratory volume in one second (FEV1) (57% vs. 23%, p=0.033), independent of age. Basal flows and FEV1 were significantly lower in asthmatics than in controls, but no difference was found between groups in forced vital capacity (FVC) and FEV in 0.5s (FEV0.5). Using receiver operating characteristic (ROC) curves, the variable with higher power to discriminate asthmatics from healthy controls was a bronchodilator response (% of change from basal above the coefficient of repeatability) of 25% in forced expiratory flow between 25% and 75% (FEF25–75) with 41% sensitivity, 80% specificity. The higher positive likelihood ratio for asthma equalled three for a bronchodilator response of 11% in FEV0.5 (sensitivity 30%, specificity 90%).

Conclusions

In this sample of Chilean preschoolers, spirometry had a very high performance and bronchodilator response was very specific but had low sensitivity to confirm asthma diagnosis.

Keywords:
Asthma
Bronchodilator response
Diagnosis
Preschoolers
Spirometry

Article

These are the options to access the full texts of the publication Allergologia et Immunopathologia
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Allergologia et Immunopathologia

Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.