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Vol. 44. Issue 1.
Pages 59-65 (January - February 2016)
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Vol. 44. Issue 1.
Pages 59-65 (January - February 2016)
Original Article
DOI: 10.1016/j.aller.2015.02.003
Urinary leukotriene and Bcl I polymorphism of glucocorticoid receptor gene in preschoolers with recurrent wheezing and high risk of asthma
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M. Moralesa, C. Floresa, K. Pinob, J. Angulob, M. López-Lastrab, J.A. Castro-Rodrigueza,
Corresponding author
jacastro17@hotmail.com

Corresponding author.
a Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
b Molecular Virology Laboratory/Instituto Milenio de Inmunologia e Inmunoterapia, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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Figures (1)
Tables (3)
Table 1. Demographic and respiratory illnesses characteristics between cases (+API) and controls (−API).
Table 2. Comparison of Bcl I polymorphism of glucocorticoid receptor gene and urinary LTE4 levels between cases (positive API) and controls (negative API).
Table 3. Multivariate logistic regression for positive API condition.
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Abstract
Background

Urinary leukotriene (LTE4) is an important marker of airway inflammation presence. A relationship between single nucleotide polymorphism in the glucocorticoid receptor (GCR) gene promoter (Bcl I polymorphism), development of asthma and sensitivity to glucocorticoids has been hypothesised.

Objective

To explore the possible association between the Bcl I polymorphism and baseline levels of urinary LTE4 in preschoolers with recurrent wheezing episodes. We prospectively enrolled and classified 86 preschoolers based on the risk of developing asthma (by the Asthma Predictive Index [API]).

Methods

At admission standardised questionnaires for demographics and respiratory illness characteristics were completed. The Bcl I polymorphism of the GCR was determined by a PCR–RFLP assay from blood samples, and urinary leukotriene was assessed from urine samples by an enzyme immunoassay.

Results

We enrolled 86 preschoolers (46 with positive API and 40 with negative API). There were no statistical differences in demographic, respiratory illnesses and wheezing episodes characteristics between both groups. Also, the prevalence of Bcl I polymorphism was similar between positive vs. negative API groups (34.8% vs. 38.9% for homozygote GG, 56.5% vs. 52.8% for heterozygote GC, 8.7% vs. 8.3% for homozygote CC, respectively, p=0.94). However, urinary LTE4 (median [IQR]) was higher in preschoolers with positive than negative API (7.18 [5.57–8.96pg/ml] vs. 6.42 [3.96–8.07pg/ml], p=0.02, respectively).

Conclusions

In our population, wheezing preschoolers with positive API exhibit higher levels of urinary LTE4 than those with negative API; but there were no differences in Bcl I polymorphism of the GCR.

Keywords:
Asthma Predictive Index
Urinary leukotriene
Preschoolers
Wheezing
Asthma
Bcl I polymorphism
Glucocorticoid receptor gene
Abbreviations:
API
LTE4
LTRA
ICS
GCR
GCS
IQR
RSV

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