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Inicio Allergologia et Immunopathologia The roles of toll like receptor 3, 7 and 8 in allergic rhinitis pathogenesis
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Vol. 46. Issue 5.
Pages 503-507 (September - October 2018)
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Vol. 46. Issue 5.
Pages 503-507 (September - October 2018)
Review
DOI: 10.1016/j.aller.2017.09.026
The roles of toll like receptor 3, 7 and 8 in allergic rhinitis pathogenesis
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A. Golshiri-Isfahania, M. Amizadehb,
Corresponding author
, M.K. Arababadic,d
a Department of Otolaryngology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
b Department of Otolaryngology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
c Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
d Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
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Abstract

Allergic rhinitis, as an allergic and nasal hypersensitivity disease, is associated with the inflammation of nasal mucosa. It appears that innate immune receptors are the important risk factors in the pathogenesis of the inflammatory disease. Toll-like receptors (TLRs) are the most important receptors of innate immunity; their crucial roles in the recognition of allergens and subsequently pathogenesis of allergic diseases have been evaluated recently. TLR3, 7 and 8 are the intracellular members of the innate immune receptors and recognize intracellular single and double strand RNAs. This review article collected the investigations regarding the roles of TLR3, 7 and 8 in the allergic rhinitis pathogenesis.

Keywords:
Allergic rhinitis
TLR3
TLR7
TLR8
Inflammation
Abbreviations:
AP-1
DAMP
IRAK1
LBP
LPS
MAPK
MD2
MHC
MYD88
NADPH
NF-κB
PAMP
PRR
TAK1
TIRAP
TLR
TRAF6
TRAM
TRIF

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