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Inicio Allergologia et Immunopathologia Tear osteopontin level and its relationship with local Th1/Th2/Th17/Treg cytokin...
Journal Information
Vol. 46. Issue 2.
Pages 144-148 (March - April 2018)
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Vol. 46. Issue 2.
Pages 144-148 (March - April 2018)
Original Article
DOI: 10.1016/j.aller.2017.05.005
Tear osteopontin level and its relationship with local Th1/Th2/Th17/Treg cytokines in children with allergic conjunctivitis
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A. Yan, G. Luo, Z. Zhou, W. Hang, D. Qin
Corresponding author
qindajun333@qq.com

Corresponding author.
Department of Ophthalmology, Yi Chang Hospital of Traditional Chinese Medicine, Yi Chang, China
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Figures (1)
Tables (3)
Table 1. Demographic characteristic of PAC, SAC and normal controls.
Table 2. Comparison of Tear Th cytokines between AC children and normal controls.
Table 3. Relationship between tear OPN level and Th cytokines in AC and control children.
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Abstract
Background

Allergic conjunctivitis (AC) is one of the most common allergic ocular diseases worldwide. Osteopontin (OPN), as a recently described Th2 inflammation related protein, may play a role in the pathogenesis of AC. The aim of this study was to identify the expression of OPN in children with AC.

Methods

Eighty AC children (seasonal and perennial AC) and twenty controls were enrolled in this study. Serum and tears of different time points (during and out of the pollen season) were collected and used for enzyme-linked immunosorbent assay (ELISA) of OPN and T-help cell related cytokines, respectively. The relationship between serum and tears OPN and Th1/2/17Treg related cytokines as well as disease severity were analysed.

Results

Our results showed that expression of tear OPN protein by perennial AC patients increased significantly compared with controls or seasonal AC patients out of the pollen season. Tear OPN expression was positively related to local Th2/17 cytokines and negatively related to IL-10 and TGF-β expression. The tear OPN expression was also significantly related to disease severity.

Conclusion

Tear OPN reflects the local clinical status of ocular allergy and might play an important pathophysiological role in local Th2/17/Treg inflammation in children with AC.

Keywords:
Allergic conjunctivitis
Osteopontin
Cytokines

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