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Vol. 47. Issue 3.
Pages 214-220 (May - June 2019)
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Vol. 47. Issue 3.
Pages 214-220 (May - June 2019)
Original Article
DOI: 10.1016/j.aller.2018.07.010
Taurine administration prevents the intestine from the damage induced by beta-lactoglobulin sensitization in a murine model of food allergy
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S. Aïnad-Tabet
Corresponding author
haddisoraya@yahoo.fr

Corresponding author.
, H. Grar, A. Haddi, H. Negaoui, A. Guermat, O. Kheroua, D. Saïdi
Laboratory of Physiology of Nutrition and Food Safety, Department of Biology, Faculty of Natural and Life Sciences, University of Oran1 Ahmed Ben Bella, 31000 Oran, Algeria
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Table 1. Effect of taurine administration on morphological measurements in the small intestine.
Abstract
Background

Allergy to cow's milk proteins has often been associated with dysfunction of the intestinal mucosa caused by chronic inflammation in infants. This study evaluated the protective effect of taurine on intestinal damage induced by beta-lactoglobulin (β-Lg) in Balb/c mice used as an animal model of allergy to cow's milk proteins.

Methods

Balb/c mice were treated with taurine administered orally by gavage (3mmol/kg/day) or intraperitoneally (100mg/kg/day) for two weeks, then sensitized intraperitoneally with β-Lg. The electrophysiological parameters: active ion transport of chloride (Short-circuit current: Isc) and the passive ion permeability (Conductance: G) were measured ex vivo in Ussing chamber by intestine challenge with β-Lg. Histological study was used to assess gut inflammation. Serum levels of TNF-α and IL-6 were measured. Serum IgG and IgE anti-β-Lg were determined by ELISA.

Results

Compared with sensitized mice, β-Lg challenge of intestinal epithelium of taurine-pre-treated mice in Ussing chamber did not influence the intensity of Isc, nor produce any changes in the G, reflecting a reduction in the secretory response and epithelial permeability. Histological and morphometric analysis showed that taurine reduced the intestinal damage and limited intestine retraction caused by β-Lg sensitization. No statistically significant difference in the serum levels of TNF-α or IL-6 was found after oral or intraperitoneal administration of taurine. Treatment with taurine significantly decreased the IgG (p<0.001) and IgE anti β-Lg levels (p<0.05).

Conclusions

These results have for the first time provided evidence that pre-treatment with taurine appears to prevent intestinal damage induced by β-Lg.

Keywords:
Taurine
Intestinal damage
β-Lactoglobulin
Epithelial permeability
Ussing chamber
Pro-inflammatory cytokines

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