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Allergologia et Immunopathologia
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Journal Information
Vol. 45. Issue S1.
Sagunto's Second Scientific Meeting on Immunotherapy. Regulation and Current Situation.
Pages 30-35 (December 2017)
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Vol. 45. Issue S1.
Sagunto's Second Scientific Meeting on Immunotherapy. Regulation and Current Situation.
Pages 30-35 (December 2017)
DOI: 10.1016/j.aller.2017.09.008
Tablet-based sublingual immunotherapy for respiratory allergy
L. Prieto
Sección de Alergologia, Hospital Dr Peset and Universidad de Valencia, Spain
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Figures (1)
Tables (4)
Table 1. Standardized mean differences (SMDs) for SLIT-tablets and pharmacotherapies for seasonal and perennial allergic rhinitis.21
Table 2. Primary and secondary outcomes used in allergen immunotherapy trials.26
Table 3. Clinical weighting of each domain in the composite asthma severity index (CASI).27
Table 4. Defining moderate asthma exacerbation.28
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Allergic respiratory disease represents a significant and expanding health problem worldwide. The gold standard of therapeutic intervention is still grucocorticosteroids, although they are not effective in all patients and may cause side effects. Allergen Immunotherapy has been administrated as subcutaneous injections for treatment of allergic rhinoconjunctivitis and asthma and has been practiced for the past century. Sublingual immunotherapy (SLIT) tablets are now available for grass- or ragweed-induced rhinoconjunctivitis and will be available in Spain for house dust mite (HDM)-induced rhinoconjunctivitis and asthma in the next months. In this review, new developments in the field of tablet-based SLIT for respiratory allergy are summarized, with special emphasis on HDM-induced allergic rhinitis and asthma. SLIT tablets are the best-documented immunotherapy products on the market and represent a more patient-friendly concept because they can be self-administrated at home.

Allergen immunotherapy
Tablet-based immunotherapy
Sublingual immunotherapy
Allergic rhinitis
Respiratory allergy


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