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Inicio Allergologia et Immunopathologia Serum vitamin D levels decrease in children with acute urticaria
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Vol. 44. Issue 6.
Pages 512-516 (November - December 2016)
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Vol. 44. Issue 6.
Pages 512-516 (November - December 2016)
Original Article
DOI: 10.1016/j.aller.2016.04.007
Serum vitamin D levels decrease in children with acute urticaria
B. Ozdemira,
Corresponding author

Corresponding author.
, B.T. Köksalb, N.M. Karakaşa, O.Y. Ozbekb
a Department of Pediatrics, Baskent University Faculty of Medicine, Ankara, Turkey
b Department of Pediatric Allergy, Baskent University Faculty of Medicine, Ankara, Turkey
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Tables (1)
Table 1. Clinical characteristics and laboratory parameters of the study subjects.

Acute urticaria is an immune-inflammatory disease, characterised by acute immune activation. There has been increasing evidence showing that vitamin D deficiency is associated with increased incidence and severity of immune-inflammatory disorders.


The aim of this study was to evaluate serum vitamin D levels in acute urticaria.


We enrolled 30 children with acute urticaria and 30 control subjects. Concentrations of 25-hydroxyvitamin D [25(OH)D], a biomarker of vitamin D status, were measured in serum of acute urticaria patients and compared with the control group.


There were no significant differences in baseline variables (age, gender, weight) between the groups. Vitamin D deficiency (<20ng/ml) was significantly higher in patients with acute urticaria than in control patients. Serum 25(OH)D levels were significantly lower in the study group compared to those in the control group (13.1±4.3 vs 28.2±7.4ng/mL, p<0.05). Moreover, we found negative correlation between mean duration of acute urticaria and serum vitamin D levels (p<0.01).


This study revealed a significant association of lower serum 25(OH)D concentrations with acute urticaria and an inverse relationship with disease duration. These findings may open up the possibility of the clinical use of vitamin D as a contributing factor in the pathogenesis of acute urticaria and a predictive marker for disease activity in acute urticaria. A potential role of vitamin D in pathogenesis and additive therapy in acute urticaria needs to be examined.

Acute urticaria
Skin diseases
Vitamin D


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