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Vol. 48. Issue 5.
Pages 424-429 (September - October 2020)
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Vol. 48. Issue 5.
Pages 424-429 (September - October 2020)
Original Article
DOI: 10.1016/j.aller.2019.07.012
Serum sickness-like reactions in Iranian children: a registry-based study in a referral center
Azam Mohsenzadeha,b, Masoud Movahedib, Mohammad Saatchic, Nima Parvanehb, Mansoureh Shariatb, Asghar Aghamohammadib, Mohammad Gharagozloub,
Corresponding author

Corresponding author.
a Department of Pediatrics, Lorestan University of Medical Sciences, Khorramabad, Iran
b Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
c Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
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Figures (1)
Tables (3)
Table 1. Frequency of Clinical Symptoms in SSRL Patients by sex.
Table 2. Mean ± SD duration of onset of symptoms after consuming the medication.
Table 3. Laboratory characteristics of the patients.
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Introduction and Objectives

Considering that no studies have been done on a comprehensive review of Serum sickness-like reactions patients (SSLRs) at a referral center in Iran so far, this study aimed to determine the clinical and laboratory characteristics of children with SSRL in Tehran Children’s Medical Center.


The present study was a registry-based study in which the data of 94 SSLRs patients registered in a two-year period were investigated. Confirmation of fever, rash, urticaria, arthralgia / arthritis and history of antibiotic consumption up to three weeks before were the criteria for the diagnosis.


Fifty-one (54 %) patients were male with mean age of 56 ± 30 months and there was no significant difference in the age of the two genders. The mean onset of symptoms before hospitalization were 3.8 ± 2.7 days (1–14 days); this mean was significantly higher in males than in females (4.6 ± 2.9 versus 2.9 ± 1.7 days, P-value = 0.003). Among antibiotics, Co-amoxiclav and Cefixime antibiotics had the most frequency by 31 % and 33 %, respectively as the most important incidence factor of SSLRs. The mean duration of consumption of culprit medications in the incidence of SSLRs was 5.6 ± 2.9 days with a range of 1–15 days.


This study showed that among the antibiotics, Co-amoxiclav and Cefixime are more prevalent and a review of prescribing these two antibiotics for the treatment of the children’s infections is essential if this finding is confirmed by other Iranian scholars.

serum sickness-like reactions
Iranian children


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