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Inicio Allergologia et Immunopathologia Sensitization to grass allergens: Phl p1, Phl p5 and Phl p7 Phl p12 in adult and...
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Vol. 47. Issue 6.
Pages 579-584 (November - December 2019)
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Vol. 47. Issue 6.
Pages 579-584 (November - December 2019)
Original Article
DOI: 10.1016/j.aller.2019.04.006
Sensitization to grass allergens: Phl p1, Phl p5 and Phl p7 Phl p12 in adult and children patients in Beja (Southern Portugal)
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Elsa Almeidaa,b,
Corresponding author
elsaalmeida.1983@gmail.com

Correspondence author.
, Elsa Caeiroc,e, Ana Todo-Bomd, Ana Duartef, Luiz Gazarinib,e
a Serviço de Patologia Clínica, Hospital José Joaquim Fernandes, Rua Dr. António Fernando Covas Lima, 7801-849 Beja, Portugal
b Universidade de Évora, Évora, Portugal
c Sociedade Portuguesa de Alergologia e Imunologia Clínica – SPAIC, Lisboa, Portugal
d Universidade de Coimbra, Coimbra, Portugal
e Instituto de Ciências Agrárias e Ambientais Mediterrânicas – ICAAM, Universidade de Évora, Évora, Portugal
f Hospital José Joaquim Fernandes, Unidade Local de Saúde do Baixo Alentejo, Beja, Portugal
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Table 1. Distribution of allergen-sensitized patients Phl p1, Phl p5, Phl p7, and Phl p12 by different levels of IgE (KUA/L). Each level corresponds to a different clinical interpretation that varies from indeterminable to very high. The majority of patients presented sensitization to more than one allergen.
Table 2. Descriptive statistics, means, medians and standard deviations of Phl p1, Phl p5, Phl p7, and Phl p12 (KUA/L) allergens in <18 and ≥ 18 groups.
Table 3. Representation of the total number and percentage of children and adults with different sensitization profiles analyzed.
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Abstract
Background

In Portugal, the pollen types most implicated in respiratory allergy are grasses, olive and parietaria. The knowledge of sensitizations to molecular allergens in children and adults can contribute to better diagnosis and treatment of this pathology.

Methods

ImmunoCAP singleplex technology was used for molecular allergens and Phadia 250® automatic equipment. g205 (Phl p1); g215 (Phl p5b); g210 (Phl p7); and g212 (Phl p12) allergen determinations were made in 45 patients with positive grass sensitization tests.

Results

The majority of patients are sensitized to Phl p1 (91%) and Phl p1+/Phl p5−/Phl p7−/Phl p12− was the most dominant profile (40%). In the adult group, the IgE averages for Phl p1 were approximately 10.46, while they were 8.43 for Phl p5, 0.69 for Phl p7, and 0.06 for Phl p12. In the child group, these values were higher: 22.49, 20.23, 3.89, and 0.35, respectively. For allergens Phl p1, Phl p5, and Phl p7, these differences between the child and adult population were not statistically significant (p=0.754, p=0.806 and p=0.102, respectively), but for Phl p12, a statistically significant difference (p=0.018) was observed.

Conclusions

IgE antibodies Phl p1 is the most important allergic marker and sensitivities caused by Phl p12 give rise to higher IgE values in children.

Keywords:
Grass allergy
Molecular allergens
Phl p 1
Phl p 5
Phl p7
Phl p12
Portugal

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