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Inicio Allergologia et Immunopathologia Sarcoidosis following specific immunotherapy: more than just coincidence?
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Vol. 35. Issue 1.
Pages 1-40 (January 2007)
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Vol. 35. Issue 1.
Pages 1-40 (January 2007)
DOI: 10.1157/13099093
Sarcoidosis following specific immunotherapy: more than just coincidence?
Sarcoidosis tras la inmunoterapia específica: ¿más que una simple coincidencia?
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O. El Jundia, G. Karakayaa, A. Fuat Kalyoncua
a Department of Chest Diseases. Adult Allergy Unit. Hacettepe University School of Medicine. Ankara. Turkey
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Table. I. Demographic and clinical data of the cases
Although not yet clear, the etiology of sarcoidosis may be linked to seasonal, environmental and genetic factors; mycobacterial or other infections. To the best of our knowledge there is no data suggesting any connection between the onset of sarcoidosis and specific allergen immunotherapy in the medical literature. During the 11-year period between 1993 and 2005, a total of 91 sarcoidosis cases have been diagnosed at our institution. Out of these, here we present 3 cases of de novo sarcoidosis occurring after receiving specific immunotherapy (SIT) at the same institution (two of which had acquired the disease in Sweden where they had resided for a short time). We suggest that sarcoidosis may occur in patients following (SIT) probably via an abnormal immunological host response to an unknown antigenic trigger.
Keywords:
Etiology
Sarcoidosis
Specific Immunotherapy
Aunque no esta claro, la etiología de la sarcoidosis puede estar liga a la estacionalidad, ambiente, factores genéticos, micobacterias u otras infecciones. No conocemos publicaciones que sugieran una conexión entre el inicio de la sarcoidosis y la inmunoterapia específica con alergenos. Durante un período de 11 años, entre 1993 y 2005, se ha diagnosticado en nuestra institución un total de 91 casos de sarcoidosis. Aparte de estos, presentamos aquí 3 nuevos casos iniciados tras recibir inmunoterapia específica en la misma institución, dos de los cuales iniciaron el proceso en Suecia, donde habían residido por un breve periodo de tiempo. Sugerimos que la sarcoidosis puede tener lugar en pacientes tratados con inmunoterapia específica con alergenos, probablemente por un mecanismo inmunitario anormal por el desencadenamiento de una respuesta antigénica desconocida.

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