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Vol. 47. Issue 1.
Pages 73-78 (January - February 2019)
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Vol. 47. Issue 1.
Pages 73-78 (January - February 2019)
Original Article
DOI: 10.1016/j.aller.2018.03.009
Retrospective definition of reaction risk in Italian children with peanut, hazelnut and walnut allergy through component-resolved diagnosis
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M. Giovanninia, P. Comberiatib, M. Piazzab, E. Chiesac, G.L. Piacentinib, A. Bonerb, G. Zanonic, D.G. Peronid,
Corresponding author
diego.peroni@unipi.it

Corresponding author.
a Allergy Unit, Department of Pediatrics, Anna Meyer Children's University Hospital, Florence, Italy
b Department of Surgical, Stomatologic and Mother-Child Sciences, Section of Pediatrics, University of Verona, Verona, Italy
c Department of Pathology and Diagnostics, Section of Immunology, University of Verona, Verona, Italy
d Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy
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Tables (4)
Table 1. Characteristics of the study groups.
Table 2. Characteristics of severe reaction study group.
Table 3. Analysis of s-IgE positivity to peanut and hazelnut molecular allergens through ImmunoCAP®.
Table 4. Analysis of s-IgE positivity to hazelnut and walnut molecular allergens molecular allergens through ISAC®.
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Abstract
Background

Serum IgE evaluation of peanut, hazelnut and walnut allergens through the use of component-resolved diagnosis (CRD) can be more accurate than IgE against whole food to associate with severe or mild reactions.

Objectives

The aim of the study was to retrospectively define the level of reaction risk in children with peanut, hazelnut and walnut sensitization through the use of CRD.

Methods

34 patients [n=22 males, 65%; median age eight years, interquartile range (IQR) 5.0–11.0 years] with a reported history of reactions to peanut and/or hazelnut and/or walnut had their serum analyzed for specific IgE (s-IgE) by ImmunoCAP® and ISAC® microarray technique.

Results

In children with previous reactions to peanut, the positivity of Arah1 and Arah2 s-IgE was associated with a history of anaphylaxis to such food, while the positivity of Arah8 s-IgE were associated with mild reactions. Regarding hazelnut, the presence of positive Cora9 and, particularly, Cora14 s-IgE was associated with a history of anaphylaxis, while positive Cora1.0401 s-IgE were associated with mild reactions. Concerning walnut, the presence of positive Jug r 1, Jug r 2, Jug r 3 s-IgE was associated with a history of anaphylaxis to such food. ImmmunoCAP® proved to be more useful in retrospectively defining the risk of hazelnut anaphylaxis, because of the possibility of measuring Cor a14 s-IgE.

Conclusions

Our data show that the use of CRD in patients with allergy to peanut, hazelnut and walnut could allow for greater accuracy in retrospectively defining the risk of anaphylactic reaction to such foods.

Keywords:
Peanut allergy
Hazelnut allergy
Walnut allergy
Children
Specific IgE
Component-resolved diagnostics
Abbreviations:
CRD
DBPCFC
IQR
LTPs
OAS
PR-10
SPT
s-IgE

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