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Vol. 47. Issue 1.
Pages 32-37 (January - February 2019)
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Vol. 47. Issue 1.
Pages 32-37 (January - February 2019)
Original Article
DOI: 10.1016/j.aller.2018.05.006
Prevalence of self-reported drug hypersensitivity reactions among Lithuanian children and adults
V. Kvedarienea,b,
Corresponding author

Corresponding author.
, B. Sitkauskienec, L. Tamasauskienec, O. Rudzeviciened, V. Kasiuleviciuse, G. Nekrosytea, E.R. Gomesf, P. Demolyg,h
a Clinic of Infectious, Chest diseases, Dermatology and Allergology, Institute of Clinical Medicine, M.K. Ciurlionio Street 21, LT-03101 Vilnius, Lithuania
b Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Santariskiu 2, LT-08661 Vilnius, Lithuania
c Department of Immunology and Allergology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Street 2, LT-50009 Kaunas, Lithuania
d Clinic of Children's Diseases, Faculty of Medicine, Vilnius University, Santariskiu 2, LT-08661 Vilnius, Lithuania
e Clinic of Internal Medicine, Oncology, and Family Medicine, Faculty of Medicine, Vilnius University, Santariskiu 2, LT-08661 Vilnius, Lithuania
f Immunoallergology Department, Serviço de imunoalergologia, CHP, Largo Abel Salazar, 4099-001 Porto, Portugal
g Division of Allergy, Department of Pulmonology, University Hospital of Montpellier, 8 Place Martyrs de la Résistance, 34000 Montpellier, France
h Montpellier and Pierre Louis of Epidemiology and Public Health, Sorbonne Universités, 75005 Paris, France
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Figures (1)
Tables (5)
Table 1. Characteristics of the study population.
Table 2. Type of drug-induced clinical manifestation in Lithuanian children and adults by self-reported survey.
Table 3. Culprit drugs and prevalence of self-reported DHRs in Lithuanian children and adults.
Table 4. Incidence of clinical cases of DHRs according to the group of drugs.
Table 5. Prevalence of different self-reported allergies and family history of allergy in the groups with DHRs and without DHRs.
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Introduction and objectives

Drug hypersensitivity reactions (DHRs) are the adverse effects of drugs that, when taken at doses generally tolerated by normal subjects, clinically resemble allergy. We aimed to assess the prevalence of self-reported DHRs among Lithuanian children and adults and to identify possible risk factors.

Materials and methods

A cross-sectional survey of a population visiting their general practitioners in Vilnius and Kaunas regions of Lithuania was performed. Thirty-five questions on drug allergy symptoms, in addition, food, pollen allergy and family history were included.


3222 (60.0%) children and 2148 (40.0%) adults were included in the study. 7.9% of children and 13.8% of adults reported a DHR for at least one drug (p<0.001). 69.8% of children and 47.3% of adults, who indicated DHRs, had skin symptoms. Rate of anaphylaxis was similar in both groups (about 10%). 4.5% of children and 7.3% of adults had DHRs induced by antibiotics and this was the most implicated group of drugs. Significant self-reported risk factors for DHRs were family history of DHRs (OR=6.007, 95%CI 4.756–7.587), pollen allergy (OR=2.0, 95%CI 1.573–2.544), food allergy (OR=1.92, 95%CI 1.505–2.448), female gender (OR=1.439, 95%CI 1.187–1.744) and age (OR=1.017 in favour of adults, 95%CI 1.013–1.021).


The prevalence of self-reported DHRs in Lithuania is higher among adults than children. Drug-induced skin reactions were the predominant symptom in both groups. Besides female gender and age, a positive family history of DHR and presence of pollen or food allergy may be associated with DHR.

Drug allergy
Drug hypersensitivity reaction
Self-reported risk factor


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