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Allergologia et Immunopathologia
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Vol. 43. Issue 2.
Pages 157-161 (March - April 2015)
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Vol. 43. Issue 2.
Pages 157-161 (March - April 2015)
Original Article
DOI: 10.1016/j.aller.2013.11.009
Prevalence of allergic diseases and/or allergic sensitisation in children and adolescents with type 1 diabetes mellitus
H. Villa-Novaa, A.M. Spinola-Castrob, F.E. Garciab, D. Soléa,
Corresponding author
a Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo-Escola Paulista de Medicina (UNIFESP-EPM), São Paulo, SP, Brazil
b Division of Endocrinology, Department of Pediatrics, Federal University of São Paulo-Escola Paulista de Medicina (UNIFESP-EPM), São Paulo, SP, Brazil
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Tables (3)
Table 1. Distribution of patients according to allergic disease associated or not to diabetes mellitus type I (DM1).
Table 2. Distribution of diabetes mellitus type I patients according to allergic disease and positive skin prick test (SPT).
Table 3. Frequency of positive skin prick test to different allergens in diabetes mellitus type I patients according to allergic disease presented: asthma (A), rhinitis (R), asthma and rhinitis (A+R), eczema (E) or not.
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The prevalence of atopic diseases in children with type 1 diabetes mellitus (DM1) has been reported as lower. The aim of this study was to evaluate the prevalence of allergic diseases and allergic sensitisation in Brazilian children and adolescents with DM1.

Patients and methods

96 patients with DM1 (aged 4–18 years, 45 boys) followed for at least one year were evaluated for allergic disease through a detailed allergological anamnesis and skin prick tests (SPT) to inhalant allergens (Dermatophagoides pteronyssinus, D. farinae, Blomia tropicalis, Blattella germanica, Periplaneta americana, dog epithelium, cat epithelium, mix fungi), foods (cow's milk, egg-white, yolk, soy, wheat, corn), and positive (histamine 1mg/ml) and negative (saline) controls. Wheals with a mean diameter of induration equal to or greater than 3mm identified a positive SPT.


The prevalence values of rhinitis, asthma and atopic eczema (isolated or associated) were 68.0%, 59.1% and 44.4%, respectively. 20.6% of the patients had no allergic disease. 46.8% of the patients had been diagnosed with DM1 for at least four years and there was no relationship between the period of DM1 and the presence of allergic disease, nor of the gender. 48.0% patients were sensitised with predominance of D. pteronyssinus, B. topicalis and D. farinae. The frequency of positive SPT was significantly higher among patients with history of allergic disease (OR=6.98, 95%CI: 2.60–18.74, p<0.001).


The prevalence of allergic diseases and sensitisation in patients with DM1 was higher than usually expected and deserves further investigation to identify possible causes for these findings and to evaluate their importance and influence on the metabolic control.

Allergic rhinitis
Atopic eczema
Type 1 diabetes mellitus


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