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Inicio Allergologia et Immunopathologia Polymorphisms of TGFB1, TLE4 and MUC22 are associated with childhood asthma in C...
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Vol. 45. Issue 5.
Pages 432-438 (September - October 2017)
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Vol. 45. Issue 5.
Pages 432-438 (September - October 2017)
Original Article
DOI: 10.1016/j.aller.2016.10.021
Polymorphisms of TGFB1, TLE4 and MUC22 are associated with childhood asthma in Chinese population
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J.B. Chena,1, J. Zhangb,1, H.Z. Hua, M. Xuea, Y.J. Jina,
Corresponding author
goldyingji@126.com

Corresponding author.
a Department of Paediatrics, Jiangsu Taizhou People's Hospital, Taizhou, China
b Department of Gastroenterology, Jiangsu Taizhou People's Hospital, Taizhou, China
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Tables (4)
Table 1. Baseline characteristics of the subjects.
Table 2. Association of the four variants with development of asthma.
Table 3. Logistic regression analysis of the four variants with the codominant model, dominant model, and recessive model.
Table 4. Association between the genotypes of four variants and clinical feature of patients with different severity of asthma.
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Abstract
Objective

To investigate whether the genetic variants of TGFB1, TLE4, MUC22 and IKZF3 are associated with the development of asthma in Chinese children.

Methods

572 adolescent asthma patients and 590 age-matched healthy controls were included in this study. A total of four SNPs were genotyped, including rs2241715 of TGFB1, rs2378383 of TLE4, rs2523924 of MUC22, and rs907092 of IKZF3. Allele frequencies of the patients and the control group were compared by the Chi-square test. The Student t test was used to analyse the relationship between genotypes and clinical feature of the patients.

Results

Patients were found to have significantly different frequencies of allele A of rs2241715, allele G of rs2378383 and allele A of rs2523924 as compared with the controls (40.4% vs. 45.9%, p=0.01 for rs2241715; 17.2% vs. 13.4%, p=0.01 for rs2378383; 15.3% vs. 11.9%, p=0.02 for rs2523924). For patients with severe asthma, those with genotype AA/AG of rs2241715 had remarkably higher FEV1% as compared with those with genotype GG (59.1±4.3% vs. 55.4±3.7%, p<0.001). Moreover, those with genotype GG/GA of rs2378383 had remarkably lower FEV1% as compared with those with genotype AA (54.6±2.9% vs. 58.6±4.1%, p<0.001).

Conclusions

Genes TGFB1, TLE4 and MUC22 are associated with the risk of childhood asthma in Chinese population. Our results associating TGFB1 and TLE4 with clinical features of asthma suggest potential application of these parameters in the management of asthma children.

Keywords:
Asthma
Polymorphism
Susceptibility
Children
Chinese population

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