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Vol. 48. Issue 3.
Pages 259-264 (May - June 2020)
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Vol. 48. Issue 3.
Pages 259-264 (May - June 2020)
Original Article
DOI: 10.1016/j.aller.2019.06.013
Phadiatop, Phadiatop Infant and total IgE evaluated in allergic Brazilian children and adolescents
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Felipe Faria Pierottia, Carolina Sanchez Arandaa,
Corresponding author
carolaaranda@yahoo.com.br

Corresponding author at: Rua dos Otonis, 731, 04044-010, Vila Clementino, São Paulo, SP, Brazil.
, Renata Rodrigues Coccoa, Emanuel Sarinhob, Flávio Sanoc, Arnaldo Portod, Nelson Rosárioe, Herberto José Chong Netoe, Ekaterini Goudourisf, Lilian Sanches Moraesg, Neusa Falbo Wandalsenh, Márcia Carvalho Mallozih, Antônio Carlos Pastorinoi, Jackeline Motta Francoj, Maria Letícia Chavarriak, Magnus P. Borresl, Dirceu Soléa
a Federal University of São Paulo, São Paulo, SP, Brazil
b Federal University of Pernambuco, Pernambuco, Brazil
c Nipo-Brasileiro Hospital, São Paulo, Brazil
d University of Passo Fundo, Rio Grande do Sul, Brazil
e Federal University of Paraná, Paraná, Brazil
f Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
g Federal University of Mato Grosso, Mato Grosso, Brazil
h Medical University of Santo André, São Paulo, Brazil
i University of São Paulo, São Paulo, Brazil
j Federal University of Sergipe, Sergipe, Brazil
k Federal University of Goias, Goiás, Brazil
l Uppsala University, Women’s and Children’s Health, Uppsala, Sweden and Thermo Fisher Scientific, Uppsala, Sweden
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Tables (4)
Table 1. Total serum IgE levels by age group, study group and main disease.
Table 2. Distribution of participants according to the positivity of Phadiatop Europa® (PhEU) and Phadiatop Infant® according to age and main disease.
Table 3. Serum levels of total IgE (kU/L) in relation to the result of Phadiatop Europa® (PhEU) and Phadiatop Infant® (PhInf) for the total of participants evaluated.
Table 4. Sensitivity (S), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV) and accuracy (Ac) for each of the tests - Phadiatop Europa® (PhEU) and Phadiatop Infant® (PhInf) - in each age group.
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Abstract

The clinical history is of importance in the investigation of allergic diseases but does have limitations. Many allergic conditions will be over-diagnosed if anamnesis alone is used for diagnostic criteria. Serum total immunoglobulin E (TIgE) quantification, as well as panels containing allergens prevalent in the studied population, may serve as screening tests and facilitate the diagnosis of allergic disease or its exclusion. We assessed the positivity of two versions of these tests, Phadiatop Europe® (PhEU) and Phadiatop Infant® (PhInf), as well as total IgE (TigE) values in patients with a medical diagnosis of allergic disease and non-allergic individuals.

Methods

A cross-sectional study performed in eleven Brazilian pediatric allergy centers with patients divided into groups according to the primary condition and a group of assessed control subjects. They were submitted to TIgE measurement and screening tests (PhEu and PhInf).

Results

TIgE mean serum levels were significantly higher among allergic patients, especially those with asthma/rhinitis or atopic dermatitis. The positivity of the screening tests, considering the total population, was 63.8% for PhEU and 72.6% for PhInf. These increased when we evaluated only the allergic subjects. The concordance index of the two tests was Kappa=0.7 and higher among those of greater age.

Conclusions

In the assessed population, there were significantly higher levels among those with positive screening tests and PhInf showed better performance in the identification of sensitized individuals, regardless of age. This is the first study to evaluate Phadiatop and Phadiatop Infant in the same population.

Keywords:
Child
Hypersensitivity
Immunoglobulin E
Allergens
Screening tests

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