Buscar en
Allergologia et Immunopathologia
Toda la web
Inicio Allergologia et Immunopathologia Perinatal smoking exposure and risk of asthma in the first three years of life: ...
Journal Information
Download PDF
More article options
Original Article
DOI: 10.1016/j.aller.2020.03.008
Available online 19 May 2020
Perinatal smoking exposure and risk of asthma in the first three years of life: A prospective prebirth cohort study
K. Tanakaa,b,
Corresponding author

Corresponding author.
, M. Arakawac, Y. Miyakea,b
a Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
b Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Ehime, Japan
c Wellness Research Fields, Faculty of Global and Regional Studies, University of the Ryukyus, Okinawa, Japan
Article information
Full Text
Download PDF
Tables (3)
Table 1. Distribution of selected characteristics in 1304 parent-child pairs, Kyushu Okinawa Maternal and Child Health Study, Japan.
Table 2. Adjusted ORs and 95% CIs for asthma according to perinatal tobacco smoke exposure, Kyushu Okinawa Maternal and Child Health Study, Japan.
Table 3. Adjusted ORs and 95% CIs for asthma according to maternal SHS exposure during pregnancy among 920 children whose mothers were never smokers, Kyushu Okinawa Maternal and Child Health Study, Japan.
Show moreShow less

There is limited evidence on the association between prenatal smoking exposure and the risk of asthma in children. The aim of this prebirth cohort study was to investigate the association between prenatal and postnatal tobacco smoke exposure and the risk of asthma in Japanese children.


Study subjects were 1304 mother–child pairs. Information on the variables under study was obtained using repeated questionnaires that were completed by mothers, first prior to delivery, then shortly after birth and subsequently around 4, 12, 24, and 36 months after delivery. Ever asthma was defined as a maternal report of physician-diagnosed asthma at any time since birth. Current asthma was defined as the use of asthma medication at the time of the sixth survey.


Logistic regression models revealed that maternal active smoking, either before pregnancy or during pregnancy, was not associated with the risk of ever asthma or current asthma. Further, no association was observed between postnatally living with at least one household smoker and the risk of asthma. Among children whose mothers are never smokers, maternal second-hand smoke (SHS) exposure at work and/or at home during pregnancy increased the risk of ever asthma and current asthma in children; adjusted odds ratio (95% confidence intervals) for ever asthma and current asthma were 2.41 (1.13–5.05) and 4.82 (1.68–13.43), respectively.


Our findings suggest that maternal SHS exposure during pregnancy might be associated with an increased risk of ever asthma and current asthma in young children whose mothers have never smoked.

Passive smoking
Prospective studies
Second-hand smoke


These are the options to access the full texts of the publication Allergologia et Immunopathologia

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Allergologia et Immunopathologia

Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 22,50 €

Comprar ahora
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.