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Inicio Allergologia et Immunopathologia Oral rush desensitization to cow milk. Following of desensitized patients during...
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Vol. 35. Issue 5.
Pages 174-176 (September 2007)
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Vol. 35. Issue 5.
Pages 174-176 (September 2007)
DOI: 10.1157/13110311
Oral rush desensitization to cow milk. Following of desensitized patients during three years
Desensıbılızacıón oral rápıda a la leche de vaca. Seguımıento de los pacıentes durante tres años
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A. Martorell Aragonésa, R. Félix Toledoa, J C. Cerdá Mira, A. Martorell Calatayuda
a Allergy Unit. Hospital General Universitario de Valencia. Spain.
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Figure 1. --Evolution of specific IgE levels of casein (KU/l) in the patients that followed the oral rush desensitization. d: diagnosis; brd: before beginning ORD. The value 100 correspond to > 100 KU/l levels.
Table. I Results of skin prick test (SPT) with cow's milk dilutions (1/1000, 1/100, 1/10 and 1/1). Represented by the maximum dilution SPT was positive
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We report the induction of tolerance in four patients with severe IgE-mediated cow's milk allergy, with an oral rush desensitization by introducing increasing daily doses of cow's milk (CM) for 5 days under clinical conditions in order to enable the patients to tolerate 200 ml of CM daily. Our results indicate that we can induce clinical tolerance in CM allergy by oral administration of progressive doses of milk. After three years of following, the four patients are taking CM with good tolerance. Specific IgE levels of casein have decreased progressively during these three years until being not detectable in three of the four patients and also a reduction has been observed in the cutaneous skin prick test reactions to CM.
Keywords:
Cow's milk allergy
Induction of tolerance
Oral rush desensitization
Presentamos la inducción a la tolerancia de cuatro pacientes con grave alergia a la leche de vaca mediada por IgE, mediante desensibilización oral rápida ( rush), administrando diariamente dosis crecientes de leche de vaca durante 5 días, bajo vigilancia clínica, con objeto de conseguir la tolerancia de 200 ml diarios. Los resultados indican que se puede inducir la tolerancia clínica a la leche de vaca por la administración oral progresiva de la misma. Tras el seguimiento durante tres años, los cuatro pacientes toman leche de vaca con buena tolerancia. Los niveles de IgE específica a la caseína han disminuido progresivamente durante estos 3 años hasta no ser detectable en tres de los cuatro pacientes, así como se ha observado la reducción de las pruebas cutáneas realizadas con leche de vaca.

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