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Inicio Allergologia et Immunopathologia Oral immunisation with Taishan Pinus massoniana pollen polysaccharide adjuvant w...
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Vol. 45. Issue 5.
Pages 496-505 (September - October 2017)
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Vol. 45. Issue 5.
Pages 496-505 (September - October 2017)
Original Article
DOI: 10.1016/j.aller.2017.04.005
Oral immunisation with Taishan Pinus massoniana pollen polysaccharide adjuvant with recombinant Lactococcus lactis-expressing Proteus mirabilis ompA confers optimal protection in mice
J. Zhoua, K. Weia, C. Wanga, W. Donga, N. Maa, L. Zhua, L.P. Hub, H. Huangc, R. Zhua,
Corresponding author

Corresponding author.
a Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Shandong Taian 271018, PR China
b Animal Disease Prevention and Control Center of Shandong Province, Animal Husbandry and Veterinary Bureau of Shandong Province, Shandong Jinan 250022, PR China
c Shandong New Hope Liuhe Co., Ltd, New Hope Group, Shandong Qingdao, 266061, PR China
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Proteus mirabilis poses a critical burden on the breeding industry, but no efficient vaccine is available for animals.


A recombinant Lactococcus lactis expressing the ompA of P. mirabilis was used to develop a vaccine. The mucosal and systemic immune responses of the recombinant vaccine were evaluated in mice after oral immunisation. The inhibition on P. mirabilis colonisation of vaccines was also determined. Moreover, Taishan Pinus massoniana pollen polysaccharides (TPPPS) were used as adjuvants to examine the immunomodulatory effects.


The pure recombinant L. lactis vaccine significantly induced the production of specific IgA and IgG, IL-2, IL-4, IFN-γ, and T lymphocyte proliferation, and the immunised mice exhibited significant resistance to P. mirabilis colonisation. Notably, the TPPPS adjuvant vaccines induced higher levels of immune responses than the pure L. lactis.


The L. lactis as a vaccine vehicle combined with TPPPS adjuvant provides a feasible method for preventing P. mirabilis infection.

Proteus mirabilis
Lactococcus lactis
Mucosal immune


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