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Vol. 48. Issue 4.
Pages 368-373 (July - August 2020)
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Vol. 48. Issue 4.
Pages 368-373 (July - August 2020)
Original Article
DOI: 10.1016/j.aller.2020.03.011
Omalizumab treatment in adolescents with chronic spontaneous urticaria: Efficacy and safety
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M. Kahveci, O. Soyer, B. Buyuktiryaki, B.E. Sekerel, U.M. Sahiner
Corresponding author
umsahner@yahoo.com

Corresponding author.
Hacettepe University Faculty of Medicine, Department of Pediatric Allergy, 06100 Ankara, Turkey
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Tables (3)
Table 1. Characteristics of the study population.
Table 2. Laboratory findings of children with CSU.
Table 3. Treatments of CSU patients before the start of omalizumab.
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Abstract
Background

Omalizumab is useful as an add-on treatment in patients unresponsive to high doses of second-generation antihistamines. This study aimed to evaluate the efficacy and safety of omalizumab treatment in adolescents with refractory chronic spontaneous urticaria (CSU).

Methods

CSU patients aged 12–18 years old with the diagnosis of symptomatic CSU and unresponsive to classical treatment were included in the study. All patients had an urticaria-activity-score (UAS7) of ≥16 or and were treated with 300mg omalizumab every four weeks. The degree of response was classified into complete, partial and non-responders due to UAS7.

Results

A total of 29 patients were evaluated. The median age and symptom onset age of the patients was 15.2 (IQR, 12.8–16.5) years and 14.0 (IQR, 11.8–15.9) years, respectively. The median duration of urticaria was eight (IQR, 4–24) months at admission. Eleven (37.9%) patients had angioedema and ten (34.5%) patients had concomitant allergic diseases. The median age at the beginning of treatment with omalizumab was 15.4 (IQR, 12.9–16.9) years. The median symptom duration was 12 (IQR, 6.5–27.5) months before the omalizumab treatment. Twenty-eight (96.5%) of the patients (89.6% complete, 6.9% partial) achieved response; however, one patient was a non-responder (3.5%). The adverse effect was observed in one (3.4%) patient as angioedema after the third dose. Twenty-three patients were followed up for a median of 18 (IQR, 13–27) months. Relapse was observed in three (13%) patients.

Conclusions

Omalizumab is considered as an effective and safe treatment for CSU in adolescents. Relapses mostly occur within the first year after the cessation of treatment.

Keywords:
Adolescents
Chronic urticaria
Efficacy
Omalizumab
Safety
Abbreviations:
CSU
CU
IgE
IQR
LTRA
Q4W
SPT
UAS

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