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Vol. 45. Issue 5.
Pages 463-472 (September - October 2017)
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Vol. 45. Issue 5.
Pages 463-472 (September - October 2017)
Original Article
DOI: 10.1016/j.aller.2016.12.008
Molecular diagnosis of allergy to Anisakis simplex and Gymnorhynchus gigas fish parasites
A. Armentiaa,
Corresponding author

Corresponding author.
, J. Santosb, Z. Serranoa, B. Martína, S. Martínc, J. Barriob, S. Fernándezc, M. González-Sagradod, F. Pinedae, R. Palaciose
a Servicio de Alergia, Hospital Universitario Río Hortega, Spain
b Servicio de Gastroenterología, Hospital Universitario Río Hortega, Spain
c Servicio de Pediatría, Hospital Universitario Río Hortega, Spain
d Unidad de apoyo a la Investigación, Hospital Universitario Río Hortega, Spain
e Laboratorios Diater, Madrid, Spain
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Figures (2)
Tables (5)
Table 1. Clinical data and source of allergens.
Table 2. Positivity to specific allergens in component-resolved diagnosis.
Table 3. Positive skin prick tests.
Table 4. Positive allergen-specific IgE.
Table 5. Sensitivity and specificity of diagnostic methods.
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Additional material (1)

There has been an increase in the prevalence of hypersensitivity to Anisakis simplex. There are fish parasites other than Anisakis simplex whose allergenicity has not yet been studied.


To assess IgE hypersensitivity caused by fish parasite allergens in patients with gastro-allergic symptoms after consumption of fish, shellfish or cephalopods, compared with healthy subjects, pollen allergic individuals and children with digestive symptoms after eating marine food.


We carried out in vivo tests (skin prick) and in vitro tests (specific IgE determination, Western blot) and component resolved diagnostics (CRD) using microarray analysis in all patients.


CRD better detected sensitisation to allergens from marine parasites than skin prick tests and determination of specific IgE by CAP. Sensitisation to Gymnorhynchus gigas was detected in 26% of patients measured by skin prick tests and 36% measured by IgE.


The prevalence of hypersensitivity to marine parasite allergens other than Anisakis simplex should be studied, and the most appropriate technique for this is CRD.

Anisakis simplex
Gymnorhynchus gigas
Component resolved diagnosis
Molecular diagnosis
Fish parasite allergens
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r Ani s1
rCyp c1
rGad s1
nPen i 1
rDer p 10.
nBla g7
Groups 1, 4, 5 and 6 of pollens
nDer p1 and Der p2
R Alt a 1
nApi m1
Ves v5
rAni s1
rCor a 8
nArt v3


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