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Vol. 43. Issue 6.
Pages 579-583 (November - December 2015)
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Vol. 43. Issue 6.
Pages 579-583 (November - December 2015)
Original Article
DOI: 10.1016/j.aller.2014.11.001
Methylenetetrahydrofolate Reductase gene polymorphism in children with allergic rhinitis
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M. Dogrua,
Corresponding author
mdmahmut@yahoo.com

Corresponding author.
, H. Aydinb, A. Aktasa, A.A. Cırıkc
a Zeynep Kamil Woman's and Children's Diseases Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey
b Zeynep Kamil Woman's and Children's Diseases Training and Research Hospital, Center of Genetics Diagnosis, Istanbul, Turkey
c Umraniye Education and Research Hospital, Department of Otolaryngology, Istanbul, Turkey
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Tables (2)
Table 1. Comparison of groups’ sociodemographic characteristics.
Table 2. Genotype and allele frequency of the MTHFR C677T and MTHFR A1298C polymorphism, vitamin b12, folate and homocysteine levels among patients and controls.
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Abstract
Background

Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms by impairing folate metabolism may influence the development of allergic diseases. The results of studies evaluating the relationship between MTHFR polymorphisms and atopic disease are controversial. The aim of this study was to investigate the association between the polymorphisms of C677T and A1298C for MTHFR gene and allergic rhinitis (AR) in children.

Methods

Ninety patients followed up with diagnosis of allergic rhinitis in our clinic and 30 children with no allergic diseases were included in the study. All participants were genotyped for the MTHFR (C677T) and (A1298C) polymorphisms. Vitamin b12, folate and homocysteine levels were measured.

Results

The mean age of patients was 9.2±2.9 years; 66.7% of the patients were male. There was no significant difference between patient and control groups regarding gender, age and atopy history of the family (p>0.05). The frequency of homozygotes for MTHFR C677T polymorphism in the patient and control groups was 3.3% and 10%, respectively. The frequency of homozygotes for MTHFR A1298C polymorphism among groups was 26.7% and 16.7%, respectively. The association between allergic rhinitis and polymorphisms of C677T and A1298C for MTHFR gene was not statistically significant in patients compared with controls (p>0.05). There were no statistically significant differences between the patients and the control group in terms of serum vitamin b12, folate and homocysteine levels (p>0.05).

Conclusion

We found no evidence for an association between allergic rhinitis and polymorphisms of C677T and A1298C for MTHFR gene in children. Further studies investigating the relationship between MTHFR polymorphism and AR are required.

Keywords:
Methylenetetrahydrofolate Reductase
Allergic rhinitis
Child
Gene
Allergy

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