Buscar en
Allergologia et Immunopathologia
Toda la web
Inicio Allergologia et Immunopathologia Lymphocytes and B-cell abnormalities in patients with common variable immunodefi...
Journal Information
Vol. 42. Issue 1.
Pages 35-43 (January - February 2014)
Share
Share
Download PDF
More article options
ePub
Vol. 42. Issue 1.
Pages 35-43 (January - February 2014)
Original Article
DOI: 10.1016/j.aller.2012.07.016
Lymphocytes and B-cell abnormalities in patients with common variable immunodeficiency (CVID)
Visits
...
L. Berrón-Ruiza,b,c, G. López-Herreraa,b, A. Vargas-Hernándeza, D. Mogica-Martínezd, E. García-Latorrec, L. Blancas-Galiciab, F.J. Espinosa-Rosalesb, L. Santos-Argumedoa,
Corresponding author
lesantos@cinvestav.mx

Corresponding author.
a Department of Molecular Biomedicine, Center for Research and Advanced Studies, IPN, Avenida Instituto Politécnico Nacional # 2508, Colonia Zacatenco, 07360 Mexico DF, Mexico
b Immunodeficiency Research Unit, National Institute of Pediatrics SSA, Avenida Insurgentes Sur # 3700-C, Colonia Insurgentes Cuicuilco, Mexico City, Mexico
c Laboratory of Immunochemistry I, National School of Biological Sciences, IPN, Carpio y Plan de Ayala s/n, Colonia Santo Tomas, 11340 Mexico DF, Mexico
d Department of Allergy and Clinical Immunology, National Medical Center “La Raza”, IMSS, Avenida Vallejo s/n esquina Jacarandas, Colonia La Raza, 02200 Mexico DF, Mexico
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (3)
Show moreShow less
Tables (3)
Table 1. Clinical and phenotypic characteristics of CVID patients.
Table 2. Immunological features of CVID patients.
Table 3. Clinical manifestations of CVID patients grouped according to percentage of memory B cells.
Show moreShow less
Abstract
Background and aims

Common variable immunodeficiency (CVID) is a primary antibody deficiency characterised by decreased antibody production and low or normal B-cell numbers. To elucidate the clinical and immunological heterogeneity of CVID, we studied 16 patients diagnosed with CVID.

Methods

We analysed B, T and NK cell populations. We also assessed CD27 expression to define B-cell subsets and examined the expression of molecules important in B-cell proliferation and differentiation, such as the transmembrane activator and CALM interactor (TACI), inducible costimulator (ICOS), CD154 and CD40.

Results

We observed reduced B and T-cell numbers in CVID patients; this reduction was more pronounced in adults. While one group of patients (group I) showed a significant reduction in CD27+ memory B-cells, another group (group II) of patients exhibited numbers of CD27+ memory B-cells similar to the healthy donor. The frequency of B-cells and T-cells expressing CD40 and ICOS, respectively, was significantly lower in all CVID patients compared with healthy donors. Finally, a correlation between the frequency of CD27+ memory B-cells and clinical features was observed in CVID patients.

Conclusion

These results suggest that in some patients, the combined defects in both T and B-cells may account for CVID. Additionally, patients in group I exhibited an increased frequency of pneumonia and chronic diarrhoea.

Keywords:
CVID
Memory B-cells
ICOS
TACI
CD40
CD154

Article

These are the options to access the full texts of the publication Allergologia et Immunopathologia
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Allergologia et Immunopathologia

Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 22,50 €

Comprar ahora
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.