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Allergologia et Immunopathologia
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Inicio Allergologia et Immunopathologia Lymphocytes and B-cell abnormalities in patients with common variable immunodefi...
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Vol. 42. Issue 1.
Pages 35-43 (January - February 2014)
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Vol. 42. Issue 1.
Pages 35-43 (January - February 2014)
Original Article
DOI: 10.1016/j.aller.2012.07.016
Lymphocytes and B-cell abnormalities in patients with common variable immunodeficiency (CVID)
L. Berrón-Ruiza,b,c, G. López-Herreraa,b, A. Vargas-Hernándeza, D. Mogica-Martínezd, E. García-Latorrec, L. Blancas-Galiciab, F.J. Espinosa-Rosalesb, L. Santos-Argumedoa,
Corresponding author

Corresponding author.
a Department of Molecular Biomedicine, Center for Research and Advanced Studies, IPN, Avenida Instituto Politécnico Nacional # 2508, Colonia Zacatenco, 07360 Mexico DF, Mexico
b Immunodeficiency Research Unit, National Institute of Pediatrics SSA, Avenida Insurgentes Sur # 3700-C, Colonia Insurgentes Cuicuilco, Mexico City, Mexico
c Laboratory of Immunochemistry I, National School of Biological Sciences, IPN, Carpio y Plan de Ayala s/n, Colonia Santo Tomas, 11340 Mexico DF, Mexico
d Department of Allergy and Clinical Immunology, National Medical Center “La Raza”, IMSS, Avenida Vallejo s/n esquina Jacarandas, Colonia La Raza, 02200 Mexico DF, Mexico
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Tables (3)
Table 1. Clinical and phenotypic characteristics of CVID patients.
Table 2. Immunological features of CVID patients.
Table 3. Clinical manifestations of CVID patients grouped according to percentage of memory B cells.
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Background and aims

Common variable immunodeficiency (CVID) is a primary antibody deficiency characterised by decreased antibody production and low or normal B-cell numbers. To elucidate the clinical and immunological heterogeneity of CVID, we studied 16 patients diagnosed with CVID.


We analysed B, T and NK cell populations. We also assessed CD27 expression to define B-cell subsets and examined the expression of molecules important in B-cell proliferation and differentiation, such as the transmembrane activator and CALM interactor (TACI), inducible costimulator (ICOS), CD154 and CD40.


We observed reduced B and T-cell numbers in CVID patients; this reduction was more pronounced in adults. While one group of patients (group I) showed a significant reduction in CD27+ memory B-cells, another group (group II) of patients exhibited numbers of CD27+ memory B-cells similar to the healthy donor. The frequency of B-cells and T-cells expressing CD40 and ICOS, respectively, was significantly lower in all CVID patients compared with healthy donors. Finally, a correlation between the frequency of CD27+ memory B-cells and clinical features was observed in CVID patients.


These results suggest that in some patients, the combined defects in both T and B-cells may account for CVID. Additionally, patients in group I exhibited an increased frequency of pneumonia and chronic diarrhoea.

Memory B-cells


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