Regístrese
Buscar en
Allergologia et Immunopathologia
Toda la web
Inicio Allergologia et Immunopathologia Low percentages of regulatory T cells in common variable immunodeficiency (CVID)...
Journal Information
Vol. 47. Issue 5.
Pages 457-466 (September - October 2019)
Share
Share
Download PDF
More article options
ePub
Vol. 47. Issue 5.
Pages 457-466 (September - October 2019)
Original Article
DOI: 10.1016/j.aller.2019.01.003
Low percentages of regulatory T cells in common variable immunodeficiency (CVID) patients with autoimmune diseases and its association with increased numbers of CD4+CD45RO+ T and CD21low B cells
Visits
2
G. López-Herreraa, N.H. Segura-Méndezb, P. O’Farril-Romanillosb, M.E. Nuñez-Nuñezc, M.C. Zarate-Hernándezd, D. Mogica-Martíneze, M.A. Yamazaki-Nakashimadaf, A.T Staines-Booneg, L. Santos-Argumedoh, L. Berrón-Ruiza,
Corresponding author
lberronruiz@yahoo.com.mx

Corresponding author.
a Unidad de Investigación en Inmunodeficiencias, Instituto Nacional de Pediatría SSA, Ciudad de México, Mexico
b Servicio de Alergia e Inmunología Clínica, Hospital de Especialidades del Centro Médico Siglo XXI, IMSS, Ciudad de México, Mexico
c Servicio de Alergia e Inmunología Clínica Pediátrica, Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”, Guadalajara, Jalisco, Mexico
d Departamento de Alergias, Hospital Universitario, Monterrey, Nuevo León, Mexico
e Servicio de Alergia e Inmunología, Centro Médico “La Raza”, IMSS, Ciudad de México, Mexico
f Servicio de Inmunología Clinica , Instituto Nacional de Pediatría SSA, Ciudad de México, Mexico
g Servicio de Inmunologia, Centro Médico Noreste IMSS, Monterrey, Nuevo León, Mexico
h Departamento de Biomedicina Molecular, CINVESTAV IPN, Ciudad de México, Mexico
This item has received
2
Visits
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (4)
Show moreShow less
Tables (1)
Table 1. Clinical characteristics of 36 CVID patients.
Abstract
Background

Common variable immunodeficiency (CVID) is a heterogeneous group of primary antibody deficiencies defined by marked reductions in serum IgG, IgA and/or IgM levels and recurrent bacterial infections. Some patients are associated with defects in T cells and regulatory T cells (Tregs), resulting in recurrent viral infections and early-onset autoimmune disease.

Methods

We analyzed whether there is an association between Tregs cells (CD4+CD25+CD127low and CD4+CD25+FoxP3+); memory T cells (CD4+CD45RO+); memory B cells (CD19+CD27-IgD-); and CD21low B cells (CD19+CD38lowCD21low); as well as autoimmune manifestations in 36 patients with CVID (25 women and 11 men, mean age 24 years), all by flow cytometry.

Results

Fourteen patients presented with autoimmune diseases (AI) (39%), including 11 with autoimmune thrombocytopenia (ITP) (31%); two with vitiligo (6%); one with systemic lupus erythematosus (LES) (3%); and one with multiple sclerosis (MS) (3%). CVID patients with AI had a reduced proportion of Tregs (both CD4+CD25+CD127low and FoxP3+ cells) compared with healthy controls. CVID patients with AI had expanded CD21low B cell populations compared with patients who did not have AI. A correlation between increased CD4+CD45RO T cell populations and reduced Tregs was also observed.

Conclusions

Our results showed that 39% of patients with CVID had AI and reduced Tregs populations. Research in this area might provide noteworthy data to better understand immune dysfunction and dysregulation related to CVID.

Keywords:
Common variable immunodeficiency
Autoimmunity
Tregs cells
CVID
CD21low B cells
CD4+CD45RO+ T cells

Article

These are the options to access the full texts of the publication Allergologia et Immunopathologia
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Allergologia et Immunopathologia

Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.