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Inicio Allergologia et Immunopathologia Is vitamin D level associated with the natural course of atopic dermatitis?
Journal Information
Vol. 46. Issue 6.
Pages 546-551 (November - December 2018)
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Vol. 46. Issue 6.
Pages 546-551 (November - December 2018)
Original Article
DOI: 10.1016/j.aller.2017.12.004
Is vitamin D level associated with the natural course of atopic dermatitis?
M. Dogru
Health Sciences University, Zeynep Kamil Woman and Children Health Practice and Research Center, Department of Pediatrics, Istanbul, Turkey
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Tables (3)
Table 1. Comparison of demographic characteristics and vitamin D status between patient group and control group.
Table 2. Comparison of demographic, clinical features and laboratory findings of the patients among subgroups.
Table 3. Comparison of demographic, clinical features and laboratory findings of the patients between persistent group and remission group of atopic dermatitis.
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Introduction and objectives

Atopic dermatitis (AD) is a chronic inflammatory disease of the skin. Apart from its well-known role on calcium metabolism, vitamin D is reported to affect skin functions. The study aims were to: compare the vitamin D levels of children with AD and healthy children; investigate the relationship between the severity of AD and vitamin D levels; and investigate the effect of vitamin D on the natural course of AD.

Patients or materials and methods

Sixty-nine patients with AD were enrolled. Seventy healthy children were assigned as control group. Clinical and demographic features of groups were recorded. The skin prick test, eosinophil counts, immunoglobulin (Ig) E levels and serum 25 OH cholecalciferol (25OHD3) levels were measured. After at least 4 years of follow-up, patients were re-evaluated for natural course of AD.


Mean 25OHD3 level was lower in patient group vs. control group; 19.86±6.7ng/mL (min–max: 6.8–40) vs. 24.07±9.08ng/mL, respectively, (p=0.002). Mean 25OHD3 levels, and vitamin D status were significantly different between AD severity groups. (p<0.05). In terms of vitamin D status in the pairwise comparison, vitamin D deficiency was greater in children with severe and moderate AD groups (respectively, p=0.005, p=0.018). In Tukey's post hoc analysis for 25OHD3 level, the 25OHD3 levels of severe AD are significantly lower than mild or moderate AD (respectively, p=0.001, p=0.026). There was a negative correlation between 25OHD3 levels and severity of AD (r=−0.480; p=0.001). In patients reassessed after 4 years: age, the age of AD onset, vitamin D deficiency, SCORAD level and severe AD were higher in the persistent group vs. remission group, 25OHD3 levels were higher in the remission group vs. persistent group (p<0.05).


Mean vitamin D levels were lower in patients with AD. A negative correlation between vitamin D levels and disease severity was documented. Vitamin D may affect the natural course of atopic dermatitis. There is a need for more comprehensive studies in this regard.

Atopic dermatitis
Vitamin D
Natural course


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