Buscar en
Allergologia et Immunopathologia
Toda la web
Inicio Allergologia et Immunopathologia Hashimoto's disease is a frequent comorbidity and an exacerbating factor of ...
Journal Information
Vol. 43. Issue 3.
Pages 249-253 (May - June 2015)
Download PDF
More article options
Vol. 43. Issue 3.
Pages 249-253 (May - June 2015)
Original Article
DOI: 10.1016/j.aller.2014.02.007
Hashimoto's disease is a frequent comorbidity and an exacerbating factor of chronic spontaneous urticaria
A. Sugiyamaa,
Corresponding author
, H. Nishiea, S. Takeuchib, M. Yoshinaric, M. Furueb
a Department of Dermatology, National Fukuoka Hospital, National Hospital Organization, 4-39-1, Yakatabaru, Minami-ku, Fukuoka 811-1394, Japan
b Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Fukuoka 812-8582, Japan
c Yoshinari Medical Clinic, 2-3-10, Ookusu, Minami-ku, Fukuoka 815-0082, Japan
Article information
Full Text
Download PDF
Tables (4)
Table 1. Reported positive rates of thyroid autoantibodies among CSU patients.
Table 2. Severity of CSU symptoms.
Table 3. Diagnosis criteria of autologous serum skin test from “The practical side of allergy test and immunotherapy” compiled under the supervision of Dr. Kazuo Akiyama at National Hospital Organization Sagamihara National Hospital.
Table 4. Results of examinations and changes in urticaria symptoms.
Show moreShow less

The precise pathogenesis of chronic spontaneous urticaria (CSU) remains unknown. However, an important association between CSU and autoimmune disorders such as Hashimoto's disease (HD) has been reported.

We investigated the frequency of HD as a comorbidity of CSU and the prevalence rate of autoreactivity among CSU patients with HD.

Patients and methods

The presence of thyroid autoantibodies and the levels of thyroid hormones were examined in 40 CSU patients who showed urticaria symptoms for >4 weeks. Patients who were diagnosed with HD, including subclinical ones, and were in need of treatment received thyroid therapy, and the changes in their urticarial symptoms were observed. An autologous serum skin test (ASST) was also performed to examine the relation of CSU with autoreactivity.


Eleven of the 40 CSU patients were diagnosed with HD, and 4 of the 5 patients who received and completed thyroid therapy showed considerable remission of urticarial symptoms during and after treatment. In addition, the rate of positive ASST results tended to be higher in CSU patients with HD (5 of 7) than in those without HD (2 of 6).


The comorbidity rate of HD in CSU patients was high, and such patients tended to have a positive ASST. Thyroid therapy in CSU patients with HD can lead to a considerable remission of urticarial symptoms, which may suggest that HD is possibly involved in the aetiology of CSU, or is at least a potential exacerbating factor for CSU.

Autoimmune urticaria
Chronic spontaneous urticaria
Hashimoto's disease
Thyroid autoantibodies
Thyroid hormone


These are the options to access the full texts of the publication Allergologia et Immunopathologia

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Allergologia et Immunopathologia

Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.