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Vol. 48. Issue 2.
Pages 107-115 (March - April 2020)
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Vol. 48. Issue 2.
Pages 107-115 (March - April 2020)
Original Article
DOI: 10.1016/j.aller.2019.08.004
Gut microbiota of children with atopic dermatitis: Controlled study in the metropolitan region of São Paulo, Brazil
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Lígia Cristina Fonseca Lahoz Mellia, Mírian Silva do Carmo-Rodriguesa, Humberto Bezerra Araújo-Filhoa, Carolina Santos Mellob, Soraia Tahanc, Antônio Carlos Campos Pignatarid, Dirceu Soléc, Mauro Batista de Moraisc,
Corresponding author
maurobmorais@gmail.com

Corresponding author.
a University Center FIEO, Osasco, SP, Brazil
b School of Nutrition, Universidade Federal da Bahia, BA, Brazil
c Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, SP, Brazil
d Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil
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Tables (4)
Table 1. Demographic, socioeconomic and environmental characteristics and overweight in children aged 5–11 with atopic dermatitis or without any allergic diseases (control group).
Table 2. Prevalence of gut microbiota constituents in children aged 5–11 with atopic dermatitis or without any allergic diseases (control group).
Table 3. Count (colony forming units/gram feces, CFU/g) of gut microbiota constituents in children aged 5–11 with atopic dermatitis or without any allergic diseases (control group).
Table 4. Multiple logistic regression analysis with atopic dermatitis as outcome variable.
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Abstract
Background

It is possible that imbalances in the composition of the gut microbiota or the relationship of the microbiota with the host may be implicated in the origin of allergy. Therefore, we studied the intestinal microbiota of children with atopic dermatitis (AD).

Methods

Cross-sectional study with 81 children aged 5–11; 23 with AD and 58 controls. Surveys were conducted to obtain demographic, socioeconomic and neonatal data. Diagnosis of AD was made based on the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Eubacteria, Bacteroidetes, Firmicutes, B. fragilis, E. coli, Lactobacillus spp., S. aureus, E. faecalis, Salmonella spp., M. smithii, Bifidobacterium spp., C. difficile and C. perfringens were quantified using real-time PCR.

Results

The analysis showed an association between presence of C. difficile (OR: 5.88; 95 % CI: 1.24; 27.98), greater abundance of bifidobacteria (OR: 11.09; 95 % CI: 2.14; 57.39) and a lower abundance of lactobacilli (OR: 0.07; 95 % CI: 0.01; 0.51) in the gut microbiota of children with AD. Counts of Eubacteria (0,05×103 and 8.49×103), B. fragilis (0.72×109 and 4.5×109), Lactobacillus spp. (0.02×108 and 0.38×108), E. coli (0.13×109 and 1.52×109) and M. smithii (0.02×108 and 0.31×108) were lower in children with AD (P<0.05).

Conclusions

This study confirmed that children living in the metropolitan area of São Paulo (Brazil) with AD have a different microbiota pattern with higher prevalence of C. difficile, lower abundance of Lactobacillus and greater abundance of bifidobacteria, regardless of socioeconomic status.

Keywords:
Children
Microbiota
Colon
Atopic dermatitis

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