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Inicio Allergologia et Immunopathologia Glycoprotein A (GARP) in children who outgrow food allergy
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Original Article
DOI: 10.1016/j.aller.2019.06.008
Available online 2 September 2019
Glycoprotein A (GARP) in children who outgrow food allergy
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Katarzyna Woicka-Kolejwaa, Joanna Jerzynskaa, Pawel Majakb, Agnieszka Koniareka, Iwona Stelmacha,
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alergol@kopernik.lodz.pl

Corresponding author.
a Department of Pediatrics and Allergy, Medical University of Lodz, N Copernicus Hospital, 71 Al. Pilsudskiego, 90-329, Lodz, Poland
b Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz, Poland
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Table 1. Baseline characteristics of study population at the age of 7–10 years.
Table 2. Associations between GARP expression above 201%, defined as dependent variable and group of independent variables in univariate and multivariate model of logistic regression analysis.
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Abstract
Background

There is little understanding of the mechanisms by which food allergy (FA) develops into persistent disease, or by which symptoms it regresses. Food allergy is a major health problem in developed countries, where the prevalence reaches up to 6% in children and 3% in the adult population.

Objective

Children with food allergy remission (FAR) and those without FAR below five years of age, were compared 7–10 years with respect to clinical data and expression of glycoprotein A repetitions predominant (GARP) on peripheral blood mononuclear cells.

Methods

Forty children with FAR and 40 children without FAR at age 7–10, in whom FA was previously diagnosed at age below five years were evaluated. In this prospective study, demographic and clinical data were taken, patients were classified as atopic based on history and serum specific IgE (sIgE) for a specific allergen. Blood samples were obtained from all patients to assess expression of GARP.

Results

We observed higher expression of GARP in children with FAR compared to children without FA (p=0.005); optimal cut-off for GARP prediction of the remission was 20.1%. Children with FAR and food-specific IgE in serum had higher expression of GARP compared to children with low food specific IgE (<0.35kU/L). Keeping pets at home decreased, and presence of allergic rhinitis increased ORs for high expression of GARP (hGARP) in our patients.

Conclusion

hGARP (>20.1%) is related with FAR in school children. Allergic rhinitis, and pets at home modify this effect of GARP. Children with allergic rhinitis have less chance of developing remission despite maintaining immune tolerance (hGARP); quite the opposite case with pets at home.

Keywords:
Children
Food allergy
Glycoprotein a
GARP

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