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Allergologia et Immunopathologia
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Inicio Allergologia et Immunopathologia Features and roles of T helper 9 cells and interleukin 9 in immunological diseas...
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Vol. 47. Issue 1.
Pages 90-104 (January - February 2019)
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Vol. 47. Issue 1.
Pages 90-104 (January - February 2019)
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DOI: 10.1016/j.aller.2018.02.003
Features and roles of T helper 9 cells and interleukin 9 in immunological diseases
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R. Yazdania, S. Shapoorib, M. Rezaeepoorb, R. Sanaeic, M. Ganjalikhani-Hakemib,
Corresponding author
mghakemi@med.mui.ac.ir

Corresponding authors.
, G. Azizid,e, W. Raef, A. Aghamohammadia, N. Rezaeia,g,h,
Corresponding author
rezaei_nima@yahoo.com

Corresponding authors.
a Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran
b Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
c Department of Immunology, School of Medicine, Iran University of Medical Science, Tehran, Iran
d Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
e Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
f Department of Immunology, MP8, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, Hampshire SO16 6YD, UK
g Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran
h Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
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Table 1. Functions of TH9 and IL-9 on different immune cells and tissues.
Table 2. Role of TH9 and IL-9 in immunological diseases.
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Abstract

T helper 9 (TH9) cells are considered as newly classified helper T cells that have an important role in the regulation of immune responses. Since these cells preferentially produce IL-9, these cells are termed TH9 cells. Recently, the role of TH9 and its signature cytokine (IL-9) has been investigated in a wide range of diseases, including autoimmunity, allergy, infections, cancer and immunodeficiency. Herein, we review the most recent data concerning TH9 cells and IL-9 as well as their roles in disease. These insights suggest that TH9 cells are a future target for therapeutic intervention.

Keywords:
TH9 cells
IL-9
Autoimmunity
Allergic
Infections
Cancer
Immunodeficiency

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