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Journal Information
Vol. 37. Issue 6.
Pages 302-308 (November - December 2009)
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Vol. 37. Issue 6.
Pages 302-308 (November - December 2009)
Original Article
DOI: 10.1016/j.aller.2009.06.003
Evaluation of phagocytes in atopic dermatitis
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W.C.N. Forte
Corresponding author
wilmanevesforte@yahoo.com.br

Corresponding author.
, V.C. Guardian, P.A. Mantovani, P.C.L. Dionigi, M.C.S. Menezes
Immunology Section of Santa Casa Medical School and Hospital, São Paulo, Brazil
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Tables (4)
Table 1. Patients’ characteristics: number and type of infections, duration of disease, total IgE, prick test, serum specific IgE, total white blood cells and neutrophils and immunological defect
Table 2. Distribution of the values of the means and standard deviations of the patients with atopic dermatitis and of the healthy individuals in relation to the chemotaxy by mononuclear phagocytes (migration distance in μ) and phagocytosis by mononuclear phagocytes (percentage of mononuclear cells that presented three or more phagocytic vacuoles within a total of 200 mononuclear cells)
Table 3. Distribution of the mean values and standard deviations of the patients with atopic dermatitis and the healthy individuals in relation to the chemotaxy by neutrophils (migration distance in μ)
Table 4. Distribution of the mean values and standard deviations of the patients with atopic dermatitis and healthy individuals in relation to phagocytosis by neutrophils (percentage of neutrophils that presented three or more phagocytic vacuoles within a total of 200 neutrophilic cells)
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Abstract
Background

Patients with atopic dermatitis frequently present recurrent infections by pyogenic bacteria or by intracellular microorganisms, suggesting an immune disorder.

Objective

Laboratorial investigation of phagocyte activity and chemotactic response by neutrophilic polymorphonuclear and mononuclear phagocytes in the peripheral blood of patients with atopic dermatitis from moderate to severe.

Methods

Through a transversal study, patients with atopic dermatitis from moderate to severe were selected. The neutrophilic and mononuclear phagocytes were separated and the phagocytic ingestion of zymosan particles was analysed, in addition to migration distance to the bacterial lipopolysaccharide chemotactic factor, comparing the results to the values obtained from healthy individuals within the same age group.

Results

Nineteen patients were selected, 11 female and 8 male. The mean age was 6.47 years (±4.65). Among the 19 patients studied, 14 (73.68%) presented a reduction in the neutrophilic and mononuclear phagocyte activity, with two (1.53%) patients presenting a reduction in the activity of both phagocytes.

Conclusion

Our results demonstrated a reduction in chemotactic response and phagocytic activity by neutrophilic and/or mononuclear phagocytes in the majority of patients with atopic dermatitis from moderate to severe. Our results were coherent with the clinical data concerning the higher incidence of infections by pyogenic bacteria and fungi in patients with atopic dermatitis, which are microorganisms that require defence by the phagocytes researched in the present study.

Keywords:
Atopic dermatitis
Phagocytic deficiency
Polymorphonuclear neutrophils
Mononuclear phagocytes

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