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Inicio Allergologia et Immunopathologia Evaluation of miR-196a2 expression and Annexin A1 level in children with bronchi...
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Vol. 48. Issue 5.
Pages 458-464 (September - October 2020)
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Vol. 48. Issue 5.
Pages 458-464 (September - October 2020)
Original Article
DOI: 10.1016/j.aller.2019.11.002
Evaluation of miR-196a2 expression and Annexin A1 level in children with bronchial asthmaEvaluation of miR-196a2 expression and Annexin A1 level in children
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A.A. Ibrahima,
Corresponding author
shaymaa_t@hotmail.com

Corresponding author.
, A. Ramadanb, A.A. Wahbya, I.H. Drazc, N.R. El Baroudyc, T.A. Abdel Hamidc
a Clinical and Chemical Pathology Department, National Research Center, Egypt
b Molecular Genetics and Enzymology Department, National Research Center, Egypt
c Pediatric Department, Cairo University, Egypt
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Table 1. Characteristics of the studied groups.
Abstract
Background

Annexin A1 (ANXA1) is an important anti-inflammatory mediator that may play a significant role in bronchial asthma. MiR-196a2 can target ANXA1 and therefore may play a role in the pathogenesis of asthma.

Aim of study

This is the first study which aimed to evaluate the expression of miR-196a2 in the serum of asthmatic children and correlate its expression with ANXA1 serum level and asthma severity.

Subjects and methods

The study included 100 asthma patients who were subdivided into three groups (mild, moderate and severe) and 50 healthy control subjects. Assessment of miR-196a2 expression and ANXA1 serum level were done using quantitative reverse transcriptase PCR (RT qPCR) and Elisa techniques, respectively.

Results

Compared to the control group, asthmatic children showed an increased ANXA1 serum level and decreased expression of miR-196a2 (p=0.001). However, ANXA1 serum level was lower and miR-196a2 expression was higher in severe asthmatic patients compared to moderate asthmatic ones (p=0.01, 0.03). Pearson's correlation coefficient revealed no significant correlations between ANXA1 serum level and miR-196a2 expression in the patient group (p=0.9).

Conclusions

Altered miR-196a2 expression and serum ANXA1 concentration may play a role in the pathogenesis of asthma. In addition, ANXA1 and miR-196a2 may represent potential diagnostic biomarkers for asthma and future targets for therapy.

Keywords:
Annexin A1
miR-196a2
Bronchial asthma
Asthmatic children

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