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Inicio Allergologia et Immunopathologia Efficacy and safety of sublingual immunotherapy with Dermatophagoides farinae dr...
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Vol. 46. Issue 2.
Pages 107-111 (March - April 2018)
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Vol. 46. Issue 2.
Pages 107-111 (March - April 2018)
Original Article
DOI: 10.1016/j.aller.2017.09.022
Efficacy and safety of sublingual immunotherapy with Dermatophagoides farinae drops in pre-school and school-age children with allergic rhinitis
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L.-X. Tanga, X.-J. Yanga, P.-P. Wanga, W.-T. Gea, J. Zhanga, Y.-L. Guob, J. Lub, J. Taia, Y.-M. Zhanga, X. Nia,b,
Corresponding author
nixin@bch.com.cn

Corresponding author.
a Department of Otolaryngology-Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
b Beijing Key Laboratory for Pediatric Diseases of Otolaryngology-Head and Neck Surgery, Beijing Pediatric Research Institute, Capital Medical University, Beijing 100020, China
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Figures (2)
Tables (3)
Table 1. Nasal symptom scores.
Table 2. Medication scores.
Table 3. Baseline characteristics and demography.
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Abstract
Background

The safety and efficacy of sublingual immunotherapy (SLIT) have been confirmed by many studies. However, in China, the research on efficacy and safety in young and older children with allergic rhinitis (AR) is still rare.

Objective

The aim of this retrospective study is to evaluate the efficacy and safety of SLIT with Dermatophagoides farinae drops in pre-school and school-age children with AR.

Methods

A total of 282 subjects aged 2–13 years with AR received a two-year course of sublingual immunotherapy along with pharmacotherapy. According to the age, patients were defined as the pre-school group (2–6 years old, n=116) and school-age group (7–13 years old, n=166). Total nasal rhinitis symptom scores (TNSS), visual analogue score (VAS) and total medication scores (TMS) were evaluated at four time points: baseline, after SLIT for half a year, one year and two years. The adverse events (AEs) were evaluated at each visit.

Results

After two-year SLIT, the four rhinitis symptom scores, TNSS, VAS and TMS scores were significantly lower than baseline (all P<0.05). The comparison of efficacy between one and two-year duration showed no significant difference in global clinical outcomes (all P>0.05). In addition, there were no significant differences between the pre-school and school-age group in TNSS (all P>0.05), VAS (all P>0.05) and TMS scores (P>0.05) after SLIT for half a year, one year and two years. No severe systemic AEs were reported.

Conclusion

SLIT with D. farinae drops is clinically effective and safe in pre-school and school-age patients with house dust mites (HDMs)-induced AR.

Keywords:
Allergic rhinitis
Sublingual immunotherapy
D. farinae
Efficacy

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