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Vol. 48. Issue 1.
Pages 95-104 (January - February 2020)
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Vol. 48. Issue 1.
Pages 95-104 (January - February 2020)
DOI: 10.1016/j.aller.2019.04.009
Effects of probiotics in the treatment of food hypersensitivity in children: a systematic review
Stephanie Campos dos Santos, Tulio Konstantyner
Corresponding author

Corresponding author at: Loefgreen, 1647 - Vila Clementino, Zip Code 04040-032 São Paulo/SP, Brazil.
, Renata Rodrigues Cocco
Departamento de Pediatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, São Paulo, Brazil
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Table 1. Characteristics of the selected clinical trials and the effects of probiotics on food allergies in children.

Food allergy is considered a public health problem for children. The modulation of the intestinal microbiota seems a promising strategy for the control of allergic reactions.


To describe the effects of different forms of probiotics in pediatric food hypersensitivity treatment.

Data source

We conducted a systematic review based on clinical trials published in the PubMed and Web of Science databases. The searches were carried out using the MeSH terms "Food Hypersensitivity," "Probiotics," "Lactobacillus," and "Bifidobacterium".

Data synthesis

The final selection resulted in 18 clinical trials, which were predominantly samples of infants and pre-school children. The most-often used strain, either alone or in combination, was Lactobacillus rhamnosus GG; a placebo was mainly used in the control group. As for the vehicle, the most common forms were capsules and infant formulas, and the period of intervention ranged from four weeks to 24 months, with weekly or monthly visits to measure the outcomes. In these 18 trials, 46 analyses were performed with 27 different types of outcomes to evaluate the effects of probiotics (12 laboratory and 15 clinical). Twenty-seven of these analyses demonstrated the benefits of using these microorganisms. The SCORAD (atopic dermatitis index) and IgE levels and cytokines were the outcomes mostly evaluated.


The use of probiotics is beneficial in promoting immunomodulation and reducing clinical symptoms. However, more methodologically based research is needed to clarify the effect from each type, dose, and time of using them for the establishment of definitive care protocols.

Food hypersensitivity


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