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Inicio Allergologia et Immunopathologia Effects of mesenchymal stromal cells play a role the oxidant/antioxidant balance...
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Vol. 46. Issue 2.
Pages 136-143 (March - April 2018)
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Vol. 46. Issue 2.
Pages 136-143 (March - April 2018)
Original Article
DOI: 10.1016/j.aller.2017.06.003
Effects of mesenchymal stromal cells play a role the oxidant/antioxidant balance in a murine model of asthma
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M.A.S. Malaquiasa,
Corresponding author
mi.mv@hotmail.com

Corresponding author.
, L.A. Oyamaa, P.C. Jericóa, I. Costab, G. Padilhab, S. Nagashimaa, M. Lopes-Pachecob, C.L.K. Rebelattoc, P.V. Michelottoc, D.G. Xistob, P.R.S. Brofmanc, P.R.M. Roccob, L. de Noronhaa
a Pathology Experimental Laboratory, School of Medicine, Pontifical Catholic University of Paraná, Curitiba, Brazil
b Laboratory of Pulmonary Investigation, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
c Experimental Laboratory for Cell Culture, School of Medicine, Pontifical Catholic University of Paraná, Curitiba, Brazil
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Table 1. Statistical values of the attestation of asthma in the experimental model.
Abstract

Asthma is a heterogeneous disease characterised by chronic airway inflammation. One of the most devastating consequences of this inflammatory process is the generation of reactive oxygen and nitrogen species responsible for oxidative stress. The aim of this study is to analyse the efficiency of treatment with human bone marrow-derived mesenchymal stromal cells (hMSC) in maintaining the oxidative balance in a murine model of allergic asthma by quantifying nitrotyrosine in lung tissues. After confirmation of asthma in the experimental model, samples of lung parenchyma were submitted to immunohistochemical assessment. Intravenous administration of hMSC reduced the levels of nitrotyrosine in the ASTHMA-hMSC group compared to those in the ASTHMA-SAL group. In conclusion, therapeutic administration of hMSC had a beneficial effect on oxidative stress, reducing the levels of nitrotyrosine in lung tissues in a model of allergic asthma.

Keywords:
Asthma
Oxidative stress
Nitrotyrosine
Peroxynitrite
Mesenchymal cells
Abbreviations:
MSC
hMSC
ROS
RNS
OVA
HE
NO
GPx
SOD
CAT
FEV1
FVC

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