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Inicio Allergologia et Immunopathologia Doctors’ awareness concerning primary immunodeficiencies in Brazil
Journal Information
Vol. 43. Issue 3.
Pages 272-278 (May - June 2015)
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Vol. 43. Issue 3.
Pages 272-278 (May - June 2015)
Original Article
DOI: 10.1016/j.aller.2014.09.002
Doctors’ awareness concerning primary immunodeficiencies in Brazil
E.O. Dantasa,p,
Corresponding author

Corresponding author.
, C.S. Arandaa,p, A.M. Rêgo Silvab,p, F.S. Tavaresc,p, J.F. Severo Ferreirad,p, M.A. de Quadros Coelhoe,p, L.C. de Siqueira Kovalhukf,p, P. Roxo Júniorg,p, E.C. Toledoh,p, A.C. Porto Netoi,p, H.M.C. de Sousa Vieiraj,p, O.A. Takanok,p, F.A. Nobrea,p, F. Sanol,p, V. Nudelmanm,p, V.S. de Farias Salesn,p, G.R. Silva Segundoo,p, H.T. Villar Guedesq,p, E. Félixa,p, S.M.B. Marquesq,p, J.T.L. Mazzucchellia,p, N.F. Wandalsenr,p, J.A. Pintos,p, I.C.D. Paes Barretot,p, M.R. Silvau,p, V.E.V. Rullou,p, J.M. Francov,p, E. Damascenoa,p, K. Fahlm,p, M.I. de Moraes-Pintoa,p, D.L. Del Nerow,p, L.S.L. Moraesk,p, A. Condino-Netox,p, M.M. Vilelay,p, H. Góesz,p, K.L. Schisleraa,p, E. Mirandabb,p, E.S. Goudouriscc,p, B.T. Costa Carvalhoa,p
a Federal University of São Paulo, São Paulo, Brazil
b Federal University of Pernambuco, Recife, Brazil
c University Hospital of Brasília and Children's Hospital of Brasília, Brasília, Brazil
d Albert Sabin Children's Hospital, Fortaleza, Brazil
e State University of Montes Claros, Montes Claros, Brazil
f Federal University of Paraná, Curitiba, Brazil
g Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil
h Faculty of Medicine of São José do Rio Preto, São José do Rio Preto, Brazil
i University Hospital São Vicente de Paulo, Passo Fundo, Brazil
j Joana de Gusmão Children's Hospital, Florianópolis, Brazil
k Faculty of Medicine and University Hospital Júlio Muller, Federal University of Mato Grosso, Cuiabá, Brazil
l Nipo Brasileiro Hospital, São Paulo, Brazil
m Hospital Israelita Albert Einstein, São Paulo, Brazil
n Federal University of Rio Grande do Norte, Natal, Brazil
o Federal University of Uberlândia, Uberlândia, Brazil
p Complexo Hospitalar Universitário Professor Edgar Santos – Federal University of Bahia, Salvador, Brazil
q State University of Piauí, Teresina, Brazil
r Faculty of Medicine of ABC, Santo André, Brazil
s Federal University of Minas Gerais, Belo Horizonte, Brazil
t University Center of Pará, Belém, Brazil
u Pediatrics Department, Medicine Course of Lusiada University Center (UNILUS), Santos, Brazil
v Federal University of Sergipe, Aracajú, Brazil
w Hospital do Servidor Público Municipal, São Paulo, Brazil
x Institute of Biomedical Sciences, University of São Paulo, Brazil
y Pediatrics Department, University of Campinas Medical School, Campinas, Brazil
z Private office, Macapá, Brazil
aa Hospital Ministro Costa Cavalcanti, Foz do Iguaçu, Brazil
bb Children's Hospital Cosme e Damião, Rondônia, Brazil
cc Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Article information
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Tables (5)
Table 1. Questions about PID training and knowledge.
Table 2. Demographics of respondents.
Table 3. Physicians’ distribution according to speciality for questions 6, 8–10.
Table 4. Percentage of appropriate answers to the clinical situations associated with PID.
Table 5. Poisson's regression coefficients – final model.
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PIDs are a heterogeneous group of genetic illnesses, and delay in their diagnosis is thought to be caused by a lack of awareness among physicians concerning PIDs. The latter is what we aimed to evaluate in Brazil.


Physicians working at general hospitals all over the country were asked to complete a 14-item questionnaire. One of the questions described 25 clinical situations that could be associated with PIDs and a score was created based on percentages of appropriate answers.


A total of 4026 physicians participated in the study: 1628 paediatricians (40.4%), 1436 clinicians (35.7%), and 962 surgeons (23.9%). About 67% of the physicians had learned about PIDs in medical school or residency training, 84.6% evaluated patients who frequently took antibiotics, but only 40.3% of them participated in the immunological evaluation of these patients. Seventy-seven percent of the participating physicians were not familiar with the warning signs for PIDs. The mean score of correct answers for the 25 clinical situations was 48.08% (±16.06). Only 18.3% of the paediatricians, 7.4% of the clinicians, and 5.8% of the surgeons answered at least 2/3 of these situations appropriately.


There is a lack of medical awareness concerning PIDs, even among paediatricians, who have been targeted with PID educational programmes in recent years in Brazil. An increase in awareness with regard to these disorders within the medical community is an important step towards improving recognition and treatment of PIDs.

Immunological deficiency syndromes
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