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Inicio Allergologia et Immunopathologia Diamine oxidase levels in different chronic urticaria phenotypes
Journal Information
Vol. 43. Issue 6.
Pages 593-600 (November - December 2015)
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Vol. 43. Issue 6.
Pages 593-600 (November - December 2015)
Original Article
DOI: 10.1016/j.aller.2015.01.009
Diamine oxidase levels in different chronic urticaria phenotypes
A. Daschnera,
Corresponding author

Corresponding author.
, J. González-Fernándezb, A. Vallsa, C. de Frutosa, M. Roderob, C. Cuéllarb
a Servicio de Alergia, Instituto de Investigación Sanitaria-Hospital Universitario de la Princesa, Madrid, Spain
b Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
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Table 1. Cytokines (median and interquartile range) in serum and supernatants of Concanavalin A (Con A) or Anisakis stimulated PBMC in all studied patients. Values are in pg/ml.

Diamine oxidase (DAO) is a polyamine-degrading enzyme also implicated in histamine metabolism. Chronic urticaria (CU) has a wide spectrum of clinical presentations and causes. Anisakis sensitisation associated chronic urticaria (CU+) has been characterised as a phenotype with different clinical and immunological characteristics and possibly associated with previous acute parasitism. We aimed to analyse serum DAO levels in different CU phenotypes. We further analysed the possible association of DAO with fish eating habits.


We studied 35 CU+ patients and 39 non-sensitised CU patients (CU−) as well as 19 controls. We analysed fish-eating frequency as well as fish intake associated exacerbation of CU (FIAE) or gastro-intestinal complaints (GI). DAO levels were further analysed with respect to lymphoproliferative responses, cytokine and specific IgE production.


DAO levels were not different between CU and controls, but were significantly higher in CU+ than in CU−. CU+ patients with FIAE had lower DAO levels, but no differences were detected in patients with GI. DAO levels correlated positively with oily and canned fish consumption in CU−. In CU+, DAO levels correlated positively with specific Anisakis IgE, percentages of proliferation in Anisakis stimulated peripheral blood lymphocytes, serum IL-2 and IL-6, but correlated negatively with mitogen stimulated TGF-β in supernatants.


DAO levels in CU depend on fish-eating habits and in CU+ on the amount of specific IgE production. In the CU+ phenotype, lower levels of DAO predispose to urticaria exacerbation after fish intake, probably due to a relative insufficient enteric availability of this enzyme.

Diamine oxidase
Chronic urticaria


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