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Vol. 37. Issue 2.
Pages 80-88 (April 2009)
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Vol. 37. Issue 2.
Pages 80-88 (April 2009)
DOI: 10.1016/S0301-0546(09)71109-7
Cough affects Quality of Life in asthmatic children aged 8-14 more than other asthma symptoms
Konstantinos Th. Petsiosa,
Corresponding author

Corresponding author.
, Kostas N. Priftisb, Constantinos Tsoumakasa, Aris Perperoglouc, Elpida Hatziagoroud, John N. Tsanakasd, Ioannis Androulakisa, Vasiliki N. Matzioua
a Faculty of Nursing, National and Kapodistrian University of Athens, Greece
b Department of Allergy-Pneumonology, Penteli Children's Hospital, Greece
c Department of Statistics and Actuarial-Financial Mathematics, Aegean University, Samos, Greece
d Paediatric Respiratory Unit of the 3rd Paediatric Clinic of the Aristoteleio University, Hippokrateion General Hospital of Thessaloniki, Greece
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Tables (3)
Table I. Descriptive characteristics of sample
Table II. The association of asthma severity, asthma control and symptoms with all subscales indicating the quality of life for children (N = 200, 100 aged 4-7years and 100 aged 8-14years)
Table III. The correlation of cough, dyspnoea and wheezing with the different dimensions of QoL as measured with Disabkids Questionnaire, for children aged 8–14years (n = 100) and their parents
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Asthma may influence children's health-related quality of life (QoL) differently by various symptoms, at different severity. The primary aim of this study was to evaluate the QoL in children with asthma and describe the impact of each asthma symptom on the child's well-being at different severity levels.

Material and Methods

Two hundred randomly selected children and one of their parents who consulted an outpatient asthma clinic, participated in the study. Qol was assessed with DISABKIDS-Smiley measure for children aged 4-7 years and with DISABKIDS DCGM-37 and Asthma Module for children 8-14 year old.


Most of the children suffered from mild or moderate persistent asthma. Children with uncontrolled asthma stated lower QoL compared to partly controlled or controlled in both age groups (p<0.05 in all domains). Cough appeared to affect QoL of 8-14 year olds more than other symptoms, especially in girls. In younger children, sex (boys, p=0.039), age (p=0.045), proxy sex (father, p=0.048), frequency of doctor visits (4-6 months, p=0.001), use of beta-2 agonists (p=0.007) and father's smoking habits (p=0.015) were associated with the QoL of coughing children but no correlation between cough and QoL was detected. In the 8-14 year age group coughers reported lower QoL compared to their counterparts; moreover, cough was found to affect QoL more than other symptoms (p<0.05 in all domains).


Cough has a direct effect on asthmatic children's QoL but there is still an obvious need for research to reveal all the determinats of this effect.

Quality of life
Asthmatic children


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